TNNI1

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq]

Full Name

troponin I type 1 (skeletal, slow)

Function

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Biological Process

Biological Process cardiac muscle contraction Source:GO_Central1 Publication
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process regulation of striated muscle contraction Source:UniProtKB1 Publication
Biological Process skeletal muscle contraction Source:GO_Central1 Publication
Biological Process transition between fast and slow fiber Source:Ensembl
Biological Process ventricular cardiac muscle tissue morphogenesis Source:Ensembl

Cellular Location

cytosol
troponin complex

Anti-TNNI1 antibodies

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Mouse Anti-TNNI1 Recombinant Antibody (4G6) (CBMAB-A9399-LY)

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Target: TNNI1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4G6

Application*: SE, E

Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBXS-6119) (CBMAB-S2954-CQ)

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Target: TNNI1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-6119

Application*: E, WB

Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBXS-3689) (CBMAB-S0964-CQ)

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Target: TNNI1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-3689

Application*: P, WB

Datasheet SDS

Mouse Anti-Tnni1 Recombinant Antibody (CBYJT-4069) (CBMAB-T3485-YJ)

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Target: Tnni1

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CBYJT-4069

Application*: IC, P, E, WB

Datasheet SDS

Mouse Anti-Tnni1 Recombinant Antibody (CBYJT-4068) (CBMAB-T3484-YJ)

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Target: TNNI1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Mouse, Human

Clone: CBYJT-4068

Application*: P, WB

Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4067) (CBMAB-T3483-YJ)

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Target: TNNI1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat, Mouse

Clone: CBYJT-4067

Application*: WB, IP, IF, E

Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4066) (CBMAB-T3482-YJ)

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Target: TNNI1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4066

Application*: E, LF

Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4065) (CBMAB-T3481-YJ)

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Target: TNNI1

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYJT-4065

Application*: E

Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4063) (CBMAB-T3479-YJ)

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Target: TNNI1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4063

Application*: WB, IH, P

Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4062) (CBMAB-T3478-YJ)

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Target: TNNI1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-4062

Application*: WB, IO

Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4061) (CBMAB-T3477-YJ)

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Target: TNNI1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYJT-4061

Application*: E

Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4060) (CBMAB-T3476-YJ)

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Target: TNNI1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYJT-4060

Application*: WB, E

Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4058) (CBMAB-T3474-YJ)

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Target: TNNI1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-4058

Application*: E, WB

Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4057) (CBMAB-T3473-YJ)

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Target: TNNI1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-4057

Application*: WB, IO, SE

Datasheet SDS

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion

IEImmunoelectrophoresis
IFImmunofluorescence
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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