TNNI1

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq]
Full Name
troponin I type 1 (skeletal, slow)
Function
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Biological Process
Biological Process cardiac muscle contraction Source:GO_Central1 Publication
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process regulation of striated muscle contraction Source:UniProtKB1 Publication
Biological Process skeletal muscle contraction Source:GO_Central1 Publication
Biological Process transition between fast and slow fiber Source:Ensembl
Biological Process ventricular cardiac muscle tissue morphogenesis Source:Ensembl
Cellular Location
cytosol
troponin complex
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Anti-TNNI1 antibodies

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Mouse Anti-TNNI1 Recombinant Antibody (4G6) (CBMAB-A9399-LY)

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Target: TNNI1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4G6
Application*: SE, E
Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBXS-6119) (CBMAB-S2954-CQ)

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Target: TNNI1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-6119
Application*: E, WB
Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBXS-3689) (CBMAB-S0964-CQ)

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Target: TNNI1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-3689
Application*: P, WB
Datasheet SDS

Mouse Anti-Tnni1 Recombinant Antibody (CBYJT-4069) (CBMAB-T3485-YJ)

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Target: Tnni1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYJT-4069
Application*: IC, P, E, WB
Datasheet SDS

Mouse Anti-Tnni1 Recombinant Antibody (CBYJT-4068) (CBMAB-T3484-YJ)

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Target: TNNI1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Human
Clone: CBYJT-4068
Application*: P, WB
Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4067) (CBMAB-T3483-YJ)

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Target: TNNI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-4067
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4066) (CBMAB-T3482-YJ)

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Target: TNNI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4066
Application*: E, LF
Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4065) (CBMAB-T3481-YJ)

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Target: TNNI1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-4065
Application*: E
Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4063) (CBMAB-T3479-YJ)

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Target: TNNI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4063
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4062) (CBMAB-T3478-YJ)

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Target: TNNI1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4062
Application*: WB, IO
Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4061) (CBMAB-T3477-YJ)

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Target: TNNI1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-4061
Application*: E
Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4060) (CBMAB-T3476-YJ)

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Target: TNNI1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-4060
Application*: WB, E
Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4058) (CBMAB-T3474-YJ)

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Target: TNNI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4058
Application*: E, WB
Datasheet SDS

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4057) (CBMAB-T3473-YJ)

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Target: TNNI1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4057
Application*: WB, IO, SE
Datasheet SDS

Human TNNI1 ELISA Kit (V2LY-0626-LY4192)

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Target: TNNI1
Sensitivity: 2.43 ng/mL
Detection Range: 5-50 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Rat Tnni1 ELISA Kit (V2LY-0626-LY2780)

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Target: Tnni1
Sensitivity: 0.0034 ng/mL
Detection Range: 0.006-1.8 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS

Mouse Tnni1 ELISA Kit (V2LY-0626-LY1786)

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Target: Tnni1
Sensitivity: 0.02 ng/mL
Detection Range: 0.05-10 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Human Recombinant TNNI1 protein, His Tag (V2LY-0526-LY7420)

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Target: TNNI1
Expressed Host: E. coli
Sequence: Amino Acid: Full Length
Tag: His Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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