Sign in or Register   Sign in or Register
  |  

Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4067) (CBMAB-T3483-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNNI1 (Troponin I1, Slow Skeletal Type). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TNNI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
CBYJT-4067
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Specific for an epitope mapping between amino acids 166-187 at the C-terminus of Troponin I-SS of human origin
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 166-187

Target

Full Name
troponin I type 1 (skeletal, slow)
Introduction
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. TNNI1 is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. TNNI1 prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
Entrez Gene ID
Human7135
Mouse21952
Rat29388
UniProt ID
HumanP19237
MouseQ9WUZ5
RatP13413
Alternative Names
Troponin I1, Slow Skeletal Type; Troponin I Type 1 (Skeletal, Slow); Troponin I, Slow-Twitch Isoform; Troponin I, Slow Skeletal Muscle; SSTNI; TNN1
Function
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Biological Process
Biological Process cardiac muscle contraction Source:GO_Central1 Publication
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process regulation of striated muscle contraction Source:UniProtKB1 Publication
Biological Process skeletal muscle contraction Source:GO_Central1 Publication
Biological Process transition between fast and slow fiber Source:Ensembl
Biological Process ventricular cardiac muscle tissue morphogenesis Source:Ensembl
Cellular Location
cytosol
troponin complex
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TNNI1 Recombinant Antibody (CBYJT-4067)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare