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Rabbit Anti-TNNT1 Recombinant Antibody (CBYJT-4091) (CBMAB-T3526-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to TNNT1 (Troponin T1, Slow Skeletal Type). The antibody can be used for immunoassay techniques, such as ICC.
See all TNNT1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYJT-4091
Antibody Isotype
IgG
Application
ICC

Basic Information

Immunogen
human TNNT2
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Troponin T1, Slow Skeletal Type
Introduction
TNNT1 is a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. TNNT1 is the slow skeletal troponin T subunit. Mutations in TNNT1 cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year.
Entrez Gene ID
7138
UniProt ID
P13805
Alternative Names
Troponin T1, Slow Skeletal Type; Slow Skeletal Muscle Troponin T; Troponin T Type 1 (Skeletal, Slow); STNT; TNTS; TNT; Troponin T, Slow Skeletal Muscle
Function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Biological Process
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process negative regulation of muscle contraction Source:UniProtKB1 Publication
Biological Process sarcomere organization Source:GO_Central1 Publication
Biological Process skeletal muscle contraction Source:UniProtKB1 Publication
Biological Process slow-twitch skeletal muscle fiber contraction Source:GO_Central1 Publication
Biological Process transition between fast and slow fiber Source:Ensembl
Cellular Location
cytosol
troponin complex
Involvement in disease
Nemaline myopathy 5 (NEM5):
A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Nemaline myopathy type 5 is a severe and progressive form common among Old Order Amish. Affected infants display tremors with hypotonia and mild contractures of the shoulders and hips. Proximal contractures progressively weaken and a pectus carinatum deformity develops before children die of respiratory insufficiency, usually in the second year.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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