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Mouse Anti-TNRC6C Recombinant Antibody (CBYJT-4127) (CBMAB-T3569-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNRC6C (Trinucleotide Repeat Containing 6C). The antibody can be used for immunoassay techniques, such as ELISA.
See all TNRC6C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4127
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa181-280 from human TNRC6C (NP_061869) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 181-280

Target

Full Name
trinucleotide repeat containing 6C
Introduction
TNRC6C (Trinucleotide Repeat Containing 6C) is a Protein Coding gene. Among its related pathways are RET signaling and Innate Immune System. Gene Ontology (GO) annotations related to TNRC6C include RNA binding and nucleotide binding. An important paralog of TNRC6C is TNRC6A.
Entrez Gene ID
57690
UniProt ID
Q9HCJ0
Alternative Names
Trinucleotide Repeat Containing 6C; KIAA1582
Function
Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Biological Process
Biological Process miRNA-mediated gene silencing Source:BHF-UCL1 Publication
Biological Process miRNA-mediated gene silencing by inhibition of translation Source:UniProtKB1 Publication
Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source:UniProtKB1 Publication
Biological Process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source:UniProtKB1 Publication
Cellular Location
cytosol
nucleoplasm
P-body
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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