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Rat Anti-Tollip Recombinant Antibody (Kimmy-1) (CBMAB-T3609-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Tollip (Toll Interacting Protein). The antibody can be used for immunoassay techniques, such as WB, IP.
See all Tollip antibodies

Summary

Host Animal
Rat
Specificity
Mouse, Human
Clone
Kimmy-1
Antibody Isotype
IgG2a
Application
WB, IP

Basic Information

Immunogen
Recombinant mouse Tollip
Specificity
Mouse, Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TOLLIP Gene(Protein Coding) Toll Interacting Protein
Introduction
Tollip is a component of the signaling pathway of IL-1 and Toll-like receptors. It inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. It inhibits IRAK1 phosphorylation and kinase activity.
Entrez Gene ID
Human54472
Mouse54473
UniProt ID
HumanQ9H0E2
MouseQ9QZ06
Alternative Names
4930403G24Rik; 4931428G15Rik
Function
Component of the signaling pathway of IL-1 and Toll-like receptors (PubMed:10854325, PubMed:11751856).
Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex (PubMed:10854325).
Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856).
Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (PubMed:25042851).
The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).
In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686).
Binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:26320582).
Biological Process
Biological Process autophagy Source:UniProtKB-KW
Biological Process epithelial cell differentiation Source:UniProtKB1 Publication
Biological Process inflammatory response Source:UniProtKB-KW
Biological Process innate immune response Source:UniProtKB-KW
Biological Process interleukin-1-mediated signaling pathway Source:Ensembl
Biological Process leukocyte activation Source:UniProtKB1 Publication
Biological Process phosphorylation Source:UniProtKB1 Publication
Biological Process positive regulation of protein sumoylation Source:Ensembl
Biological Process protein localization to endosome Source:UniProtKB1 Publication
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Endosome
Early endosome
Localized to endo/exosomal vesicles.
PTM
Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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