TOLLIP
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Full Name
TOLLIP Gene(Protein Coding) Toll Interacting Protein
Function
Component of the signaling pathway of IL-1 and Toll-like receptors (PubMed:10854325, PubMed:11751856).
Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex (PubMed:10854325).
Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856).
Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (PubMed:25042851).
The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).
In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686).
Binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:26320582).
Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex (PubMed:10854325).
Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856).
Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (PubMed:25042851).
The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).
In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686).
Binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:26320582).
Biological Process
Biological Process autophagy Source:UniProtKB-KW
Biological Process epithelial cell differentiation Source:UniProtKB1 Publication
Biological Process inflammatory response Source:UniProtKB-KW
Biological Process innate immune response Source:UniProtKB-KW
Biological Process interleukin-1-mediated signaling pathway Source:Ensembl
Biological Process leukocyte activation Source:UniProtKB1 Publication
Biological Process phosphorylation Source:UniProtKB1 Publication
Biological Process positive regulation of protein sumoylation Source:Ensembl
Biological Process protein localization to endosome Source:UniProtKB1 Publication
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Biological Process epithelial cell differentiation Source:UniProtKB1 Publication
Biological Process inflammatory response Source:UniProtKB-KW
Biological Process innate immune response Source:UniProtKB-KW
Biological Process interleukin-1-mediated signaling pathway Source:Ensembl
Biological Process leukocyte activation Source:UniProtKB1 Publication
Biological Process phosphorylation Source:UniProtKB1 Publication
Biological Process positive regulation of protein sumoylation Source:Ensembl
Biological Process protein localization to endosome Source:UniProtKB1 Publication
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Endosome
Early endosome
Localized to endo/exosomal vesicles.
Endosome
Early endosome
Localized to endo/exosomal vesicles.
PTM
Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.
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Anti-TOLLIP antibodies
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CompareTarget: TOLLIP
Sensitivity: 0.0052 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Tollip
Sensitivity: 0.028 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: TOLLIP
Specificity: Human
Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: Kimmy-2
Application*: IC, IP, WB
Target: TOLLIP
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Human
Clone: Kimmy-1
Application*: WB, IP
Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: CBYJT-4157
Application*: WB
Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYJT-4156
Application*: WB, IP, IC
Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4155
Application*: E, WB
Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: SB40a
Application*: WB, F, E
Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4154
Application*: E, WB
Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4153
Application*: WB, IF
Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4152
Application*: WB, IH
Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4151
Application*: WB
Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4150
Application*: E, WB
Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4149
Application*: E, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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