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TOLLIP

This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Full Name
TOLLIP Gene(Protein Coding) Toll Interacting Protein
Function
Component of the signaling pathway of IL-1 and Toll-like receptors (PubMed:10854325, PubMed:11751856).
Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex (PubMed:10854325).
Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856).
Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (PubMed:25042851).
The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).
In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686).
Binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:26320582).
Biological Process
Biological Process autophagy Source:UniProtKB-KW
Biological Process epithelial cell differentiation Source:UniProtKB1 Publication
Biological Process inflammatory response Source:UniProtKB-KW
Biological Process innate immune response Source:UniProtKB-KW
Biological Process interleukin-1-mediated signaling pathway Source:Ensembl
Biological Process leukocyte activation Source:UniProtKB1 Publication
Biological Process phosphorylation Source:UniProtKB1 Publication
Biological Process positive regulation of protein sumoylation Source:Ensembl
Biological Process protein localization to endosome Source:UniProtKB1 Publication
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Endosome
Early endosome
Localized to endo/exosomal vesicles.
PTM
Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.
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Anti-TOLLIP antibodies

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TOLLIP Matched Antibody Pair (1251) (APMAB-1251LY)

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Target: TOLLIP
Specificity: Human
Datasheet SDS

Mouse Anti-Tollip Recombinant Antibody (Kimmy-2) (CBMAB-T3610-YJ)

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Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: Kimmy-2
Application*: IC, IP, WB
Datasheet SDS

Rat Anti-Tollip Recombinant Antibody (Kimmy-1) (CBMAB-T3609-YJ)

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Target: TOLLIP
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Human
Clone: Kimmy-1
Application*: WB, IP
Datasheet SDS

Mouse Anti-TOLLIP Recombinant Antibody (CBYJT-4157) (CBMAB-T3608-YJ)

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Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: CBYJT-4157
Application*: WB
Datasheet SDS

Mouse Anti-TOLLIP Recombinant Antibody (CBYJT-4156) (CBMAB-T3607-YJ)

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Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYJT-4156
Application*: WB, IP, IC
Datasheet SDS

Mouse Anti-TOLLIP Recombinant Antibody (CBYJT-4155) (CBMAB-T3606-YJ)

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Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4155
Application*: E, WB
Datasheet SDS

Mouse Anti-TOLLIP Recombinant Antibody (SB40a) (CBMAB-T3605-YJ)

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Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: SB40a
Application*: WB, F, E
Datasheet SDS

Mouse Anti-TOLLIP Recombinant Antibody (CBYJT-4154) (CBMAB-T3604-YJ)

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Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4154
Application*: E, WB
Datasheet SDS

Mouse Anti-TOLLIP Recombinant Antibody (CBYJT-4153) (CBMAB-T3602-YJ)

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Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4153
Application*: WB, IF
Datasheet SDS

Mouse Anti-TOLLIP Recombinant Antibody (CBYJT-4152) (CBMAB-T3601-YJ)

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Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4152
Application*: WB, IH
Datasheet SDS

Mouse Anti-TOLLIP Recombinant Antibody (CBYJT-4151) (CBMAB-T3600-YJ)

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Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4151
Application*: WB
Datasheet SDS

Mouse Anti-TOLLIP Recombinant Antibody (CBYJT-4150) (CBMAB-T3599-YJ)

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Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4150
Application*: E, WB
Datasheet SDS

Mouse Anti-TOLLIP Recombinant Antibody (CBYJT-4149) (CBMAB-T3598-YJ)

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Target: TOLLIP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4149
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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