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Mouse Anti-TP53RK Recombinant Antibody (3H4) (CBMAB-A9447-LY)

The product is antibody recognizes TP53RK. The antibody 3H4 immunoassay techniques such as: IHC, ELISA.
See all TP53RK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3H4
Antibody Isotype
IgG1, κ
Application
IHC, ELISA

Basic Information

Immunogen
TP53RK (AAH09727, 154 a.a. ~ 253 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TP53RK Gene(Protein Coding) TP53 Regulating Kinase
Entrez Gene ID
112858
UniProt ID
Q96S44
Alternative Names
BUD32; C20orf64; Nori-2; Nori-2p; PRPK; dJ101A2
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914).
The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914).
TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity).
Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806).
Biological Process
Biological Process protein phosphorylation Source:UniProtKB1 Publication
Biological Process regulation of signal transduction by p53 class mediator Source:Reactome
Biological Process tRNA processing Source:UniProtKB-KW
Biological Process tRNA threonylcarbamoyladenosine metabolic process Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Galloway-Mowat syndrome 4 (GAMOS4):
A form of Galloway-Mowat syndrome, a severe renal-neurological disease characterized by early-onset nephrotic syndrome associated with microcephaly, central nervous system abnormalities, developmental delays, and a propensity for seizures. Brain anomalies include gyration defects ranging from lissencephaly to pachygyria and polymicrogyria, and cerebellar hypoplasia. Most patients show facial dysmorphism characterized by a small, narrow forehead, large/floppy ears, deep-set eyes, hypertelorism and micrognathia. Additional variable features are visual impairment and arachnodactyly. Most patients die in early childhood.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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