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TP53RK

TP53RK (TP53 Regulating Kinase) is a Protein Coding gene. Diseases associated with TP53RK include Galloway-Mowat Syndrome 4 and Galloway-Mowat Syndrome. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity.
Full Name
TP53RK Gene(Protein Coding) TP53 Regulating Kinase
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914).
The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914).
TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity).
Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806).
Biological Process
Biological Process protein phosphorylation Source:UniProtKB1 Publication
Biological Process regulation of signal transduction by p53 class mediator Source:Reactome
Biological Process tRNA processing Source:UniProtKB-KW
Biological Process tRNA threonylcarbamoyladenosine metabolic process Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Galloway-Mowat syndrome 4 (GAMOS4):
A form of Galloway-Mowat syndrome, a severe renal-neurological disease characterized by early-onset nephrotic syndrome associated with microcephaly, central nervous system abnormalities, developmental delays, and a propensity for seizures. Brain anomalies include gyration defects ranging from lissencephaly to pachygyria and polymicrogyria, and cerebellar hypoplasia. Most patients show facial dysmorphism characterized by a small, narrow forehead, large/floppy ears, deep-set eyes, hypertelorism and micrognathia. Additional variable features are visual impairment and arachnodactyly. Most patients die in early childhood.

Anti-TP53RK antibodies

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Mouse Anti-TP53RK Recombinant Antibody (4B9-1H3) (CBMAB-P3735-YC)

Datasheet SDS
Target: TP53RK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4B9-1H3
Application*: E, P, WB

Mouse Anti-TP53RK Recombinant Antibody (3H4) (CBMAB-A9447-LY)

Datasheet SDS
Target: TP53RK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H4
Application*: IH, E

Mouse Anti-TP53RK Recombinant Antibody (3D7) (CBMAB-A9446-LY)

Datasheet SDS
Target: TP53RK
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3D7
Application*: WB, E

Mouse Anti-TP53RK Recombinant Antibody (2A9) (CBMAB-A9445-LY)

Datasheet SDS
Target: TP53RK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2A9
Application*: IF, E

Mouse Anti-TP53RK Recombinant Antibody (2E10) (CBMAB-A9444-LY)

Datasheet SDS
Target: TP53RK
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2E10
Application*: WB, E

Mouse Anti-TP53RK Recombinant Antibody (2E8) (CBMAB-A9443-LY)

Datasheet SDS
Target: TP53RK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E8
Application*: WB, E

Mouse Anti-TP53RK Recombinant Antibody (CBYJT-4279) (CBMAB-T3755-YJ)

Datasheet SDS
Target: TP53RK
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4279
Application*: WB

Mouse Anti-TP53RK Recombinant Antibody (CBYJT-4278) (CBMAB-T3754-YJ)

Datasheet SDS
Target: TP53RK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4278
Application*: WB, IH

Mouse Anti-TP53RK Recombinant Antibody (CBYJT-4277) (CBMAB-T3753-YJ)

Datasheet SDS
Target: TP53RK
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4277
Application*: WB, IH

Mouse Anti-TP53RK Recombinant Antibody (CBYJT-4276) (CBMAB-T3752-YJ)

Datasheet SDS
Target: TP53RK
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4276
Application*: WB, IH

Mouse Anti-TP53RK Recombinant Antibody (CBYJT-4275) (CBMAB-T3751-YJ)

Datasheet SDS
Target: TP53RK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4275
Application*: WB, IH

Mouse Anti-TP53RK Recombinant Antibody (CBYJT-4274) (CBMAB-T3750-YJ)

Datasheet SDS
Target: TP53RK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4274
Application*: E, IH, WB

TP53RK Matched Antibody Pair (1261) (APMAB-1261LY)

Datasheet SDS
Target: TP53RK
Specificity: Human

TP53RK Matched Antibody Pair (1260) (APMAB-1260LY)

Datasheet SDS
Target: TP53RK
Specificity: Human

TP53RK Matched Antibody Pair (1259) (APMAB-1259LY)

Datasheet SDS
Target: TP53RK
Specificity: Human

TP53RK Matched Antibody Pair (1258) (APMAB-1258LY)

Datasheet SDS
Target: TP53RK
Specificity: Human

TP53RK Matched Antibody Pair (1257) (APMAB-1257LY)

Datasheet SDS
Target: TP53RK
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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