Mouse Anti-TP53RK Recombinant Antibody (2E10) (CBMAB-A9444-LY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914).
TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity).
Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806).
Biological Process regulation of signal transduction by p53 class mediator Source:Reactome
Biological Process tRNA processing Source:UniProtKB-KW
Biological Process tRNA threonylcarbamoyladenosine metabolic process Source:GO_Central1 Publication
Nucleus
A form of Galloway-Mowat syndrome, a severe renal-neurological disease characterized by early-onset nephrotic syndrome associated with microcephaly, central nervous system abnormalities, developmental delays, and a propensity for seizures. Brain anomalies include gyration defects ranging from lissencephaly to pachygyria and polymicrogyria, and cerebellar hypoplasia. Most patients show facial dysmorphism characterized by a small, narrow forehead, large/floppy ears, deep-set eyes, hypertelorism and micrognathia. Additional variable features are visual impairment and arachnodactyly. Most patients die in early childhood.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Antibody Pairs
TP53RK Matched Antibody Pair (1257) (CAT#: APMAB-1257LY)
TP53RK Matched Antibody Pair (1259) (CAT#: APMAB-1259LY)
TP53RK Matched Antibody Pair (1260) (CAT#: APMAB-1260LY)
TP53RK Matched Antibody Pair (1261) (CAT#: APMAB-1261LY)
Related Products
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TP53RK Matched Antibody Pair (1259) (CAT#: APMAB-1259LY)
Mouse Anti-TP53RK Recombinant Antibody (CBYJT-4275) (CAT#: CBMAB-T3751-YJ)
Mouse Anti-TP53RK Recombinant Antibody (3D7) (CAT#: CBMAB-A9446-LY)
Mouse Anti-TP53RK Recombinant Antibody (CBYJT-4274) (CAT#: CBMAB-T3750-YJ)
Mouse Anti-TP53RK Recombinant Antibody (2A9) (CAT#: CBMAB-A9445-LY)
TP53RK Matched Antibody Pair (1261) (CAT#: APMAB-1261LY)
Mouse Anti-TP53RK Recombinant Antibody (3H4) (CAT#: CBMAB-A9447-LY)
Mouse Anti-TP53RK Recombinant Antibody (CBYJT-4278) (CAT#: CBMAB-T3754-YJ)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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