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Rabbit Anti-TPH2 Recombinant Antibody (D3E5I) (CBMAB-CP2833-LY)

The product is antibody recognizes TPH2. The antibody D3E5I immunoassay techniques such as: WB,IF.
See all TPH2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D3E5I
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu30 of human TPH2 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TPH2 Gene(Protein Coding) Tryptophan Hydroxylase 2
Introduction
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]
Entrez Gene ID
Human121278
Mouse216343
Rat317675
UniProt ID
HumanQ8IWU9
MouseQ8CGV2
RatQ8CGU9
Alternative Names
Tryptophan Hydroxylase 2; Neuronal Tryptophan Hydroxylase; Tryptophan 5-Monooxygenase 2; EC 1.14.16.4; NTPH; Tryptophan 5-Monooxygenase; Tryptophan 5-Hydroxylase 2; EC 1.14.16; ADHD7;
Biological Process
Biological Process aromatic amino acid family metabolic process Source:InterPro
Biological Process cellular response to lithium ion Source:Ensembl
Biological Process circadian rhythm Source:Ensembl
Biological Process response to activity Source:Ensembl
Biological Process response to calcium ion Source:Ensembl
Biological Process response to estrogen Source:Ensembl
Biological Process response to glucocorticoid Source:Ensembl
Biological Process response to nutrient levels Source:Ensembl
Biological Process serotonin biosynthetic process Source:UniProtKB-UniPathway
Cellular Location
cytosol
neuron projection
Involvement in disease
Major depressive disorder (MDD):
A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.
Attention deficit-hyperactivity disorder 7 (ADHD7):
A neurobehavioral developmental disorder primarily characterized by the coexistence of attentional problems and hyperactivity, with each behavior occurring infrequently alone.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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