TPH2

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]

Full Name

TPH2 Gene(Protein Coding) Tryptophan Hydroxylase 2

Biological Process

Biological Process aromatic amino acid family metabolic process Source:InterPro
Biological Process cellular response to lithium ion Source:Ensembl
Biological Process circadian rhythm Source:Ensembl
Biological Process response to activity Source:Ensembl
Biological Process response to calcium ion Source:Ensembl
Biological Process response to estrogen Source:Ensembl
Biological Process response to glucocorticoid Source:Ensembl
Biological Process response to nutrient levels Source:Ensembl
Biological Process serotonin biosynthetic process Source:UniProtKB-UniPathway

Cellular Location

cytosol
neuron projection

Involvement in disease

Major depressive disorder (MDD):
A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.
Attention deficit-hyperactivity disorder 7 (ADHD7):
A neurobehavioral developmental disorder primarily characterized by the coexistence of attentional problems and hyperactivity, with each behavior occurring infrequently alone.