Mouse Anti-TPI1 Recombinant Antibody (CBYJT-4334) (CBMAB-T3817-YJ)

Name: Mouse Anti-TPI1 Recombinant Antibody (CBYJT-4334)
SKU: CBMAB-T3817-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4334

Application

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Triosephosphate isomerase. The exact sequence is proprietary

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

C-terminus

More Infomation

Target

Full Name

TPI1 Triosephosphate Isomerase 1

Introduction

TPI1 is an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in TPI1 are associated with triosephosphate isomerase deficiency.

Entrez Gene ID

Human	7167
Mouse	21991
Rat	24849

UniProt ID

Human	P60174
Mouse	P17751
Rat	P48500

Alternative Names

Triosephosphate Isomerase 1; Triose-Phosphate Isomerase; EC 5.3.1.1; TIM; TPI; Epididymis Secretory Protein Li 49; Triosephosphate Isomerase; HEL-S-49; TPID

Function

Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.

Biological Process

Biological Process canonical glycolysis Source:Ensembl
Biological Process gluconeogenesis Source:GO_Central1 Publication
Biological Process glyceraldehyde-3-phosphate biosynthetic process Source:UniProtKB1 Publication
Biological Process glycerol catabolic process Source:GO_Central1 Publication
Biological Process glycolytic process Source:GO_Central1 Publication
Biological Process methylglyoxal biosynthetic process Source:UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

Triosephosphate isomerase deficiency (TPID):
An autosomal recessive multisystem disorder characterized by congenital hemolytic anemia, progressive neuromuscular dysfunction, susceptibility to bacterial infection, and cardiomyopathy.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-TPI1 Recombinant Antibody (CBYJT-4335) (CAT#: CBMAB-T3818-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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