TPI1

This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

TPI1 Triosephosphate Isomerase 1

Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.

Biological Process canonical glycolysis Source:Ensembl
Biological Process gluconeogenesis Source:GO_Central1 Publication
Biological Process glyceraldehyde-3-phosphate biosynthetic process Source:UniProtKB1 Publication
Biological Process glycerol catabolic process Source:GO_Central1 Publication
Biological Process glycolytic process Source:GO_Central1 Publication
Biological Process methylglyoxal biosynthetic process Source:UniProtKB

Cytoplasm

Triosephosphate isomerase deficiency (TPID):
An autosomal recessive multisystem disorder characterized by congenital hemolytic anemia, progressive neuromuscular dysfunction, susceptibility to bacterial infection, and cardiomyopathy.