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TPI1

This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Full Name

TPI1 Triosephosphate Isomerase 1

Function

Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.

Biological Process

Biological Process canonical glycolysis Source:Ensembl
Biological Process gluconeogenesis Source:GO_Central1 Publication
Biological Process glyceraldehyde-3-phosphate biosynthetic process Source:UniProtKB1 Publication
Biological Process glycerol catabolic process Source:GO_Central1 Publication
Biological Process glycolytic process Source:GO_Central1 Publication
Biological Process methylglyoxal biosynthetic process Source:UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

Triosephosphate isomerase deficiency (TPID):
An autosomal recessive multisystem disorder characterized by congenital hemolytic anemia, progressive neuromuscular dysfunction, susceptibility to bacterial infection, and cardiomyopathy.

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Anti-TPI1 antibodies

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Mouse Anti-TPI1 Recombinant Antibody (CF450) (CBMAB-FT075LY)

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Target: TPI1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CF450

Application*: ELISA, WB

Mouse Anti-TPI1 Recombinant Antibody (CBYJT-4336) (CBMAB-T3819-YJ)

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Target: TPI1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBYJT-4336

Application*: WB

Mouse Anti-TPI1 Recombinant Antibody (CBYJT-4335) (CBMAB-T3818-YJ)

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Target: TPI1

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human, Mouse, Rat

Clone: CBYJT-4335

Application*: WB, IC, IF

Mouse Anti-TPI1 Recombinant Antibody (CBYJT-4334) (CBMAB-T3817-YJ)

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Target: TPI1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBYJT-4334

Application*: WB

Mouse Anti-TPI1 Recombinant Antibody (CBYJT-4333) (CBMAB-T3816-YJ)

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Target: TPI1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4333

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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