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Mouse Anti-TPI1 Recombinant Antibody (CBYJT-4336) (CBMAB-T3819-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TPI1 (Triosephosphate Isomerase 1). The antibody can be used for immunoassay techniques, such as WB.
See all TPI1 antibodies
Published Data
Fig.1 Western blot analysis of galectin-1, peroxiredoxin 1 and triosephosphate isomerase (TIM).
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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJT-4336
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Triosephosphate isomerase. The exact sequence is proprietary
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
TPI1 Triosephosphate Isomerase 1
Introduction
TPI1 is an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in TPI1 are associated with triosephosphate isomerase deficiency.
Entrez Gene ID
Human7167
Mouse21991
Rat24849
UniProt ID
HumanP60174
MouseP17751
RatP48500
Alternative Names
Triosephosphate Isomerase 1; Triose-Phosphate Isomerase; EC 5.3.1.1; TIM; TPI; Epididymis Secretory Protein Li 49; Triosephosphate Isomerase; HEL-S-49; TPID
Function
Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
Biological Process
Biological Process canonical glycolysis Source:Ensembl
Biological Process gluconeogenesis Source:GO_Central1 Publication
Biological Process glyceraldehyde-3-phosphate biosynthetic process Source:UniProtKB1 Publication
Biological Process glycerol catabolic process Source:GO_Central1 Publication
Biological Process glycolytic process Source:GO_Central1 Publication
Biological Process methylglyoxal biosynthetic process Source:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Triosephosphate isomerase deficiency (TPID):
An autosomal recessive multisystem disorder characterized by congenital hemolytic anemia, progressive neuromuscular dysfunction, susceptibility to bacterial infection, and cardiomyopathy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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