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Mouse Anti-TPM3 Antibody (CG3) (CBMAB-1699CQ)

This product is a mouse antibody that recognizes TPM3. The antibody CG3 can be used for immunoassay techniques such as: FC, IF, IHC, IP, WB.
See all TPM3 antibodies

Summary

Host Animal
Mouse
Specificity
Chicken, Human, Rodent
Clone
CG3
Antibody Isotype
IgM
Application
FC, IF, IHC, IP, WB

Basic Information

Immunogen
Purified chicken gizzard tropomyosin (Full length protein)
Specificity
Chicken, Human, Rodent
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
In Human, aa 29-44 encoded by Exon 1b of TPM3 (AERLQREVEGERRAREQ)

Target

Full Name
TPM3
Introduction
This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. The protein binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Diseases associated with TPM3 include Myopathy, Congenital, With Fiber-Type Disproportion and Nemaline Myopathy 1, Autosomal Dominant Or Recessive. Among its related pathways are Striated Muscle Contraction and Pathways in cancer.
Entrez Gene ID
Human7170
Chicken770103
UniProt ID
HumanP06753
ChickenH9L074
Alternative Names
tropomyosin 3
Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Biological Process
Biological Process actin filament organization Source:GO_Central1 Publication
Biological Process muscle contraction Source:GO_Central1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Involvement in disease
Nemaline myopathy 1 (NEM1):
A form of nemaline myopathy with autosomal dominant or recessive inheritance. Nemaline myopathies are disorders characterized by muscle weakness of varying onset and severity, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Autosomal dominant NEM1 is characterized by a moderate phenotype with onset between birth and early second decade of life. Weakness is diffuse and symmetric with slow progression often with need for a wheelchair in adulthood. The autosomal recessive form has onset at birth with moderate to severe hypotonia and diffuse weakness. In the most severe cases, death can occur before 2 years. Less severe cases have delayed major motor milestones, and these patients may walk, but often need a wheelchair before 10 years.
Myopathy, congenital, with fiber-type disproportion (CFTD):
A genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions.
Cap myopathy 1 (CAPM1):
A rare congenital skeletal muscle disorder characterized by the presence of cap-like structures which are well demarcated and peripherally located under the sarcolemma and show abnormal accumulation of sarcomeric proteins. Clinical features are early onset of hypotonia and slowly progressive muscle weakness. Respiratory problems are common.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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