Mouse Anti-TPMT Recombinant Antibody (CBYJT-4356) (CBMAB-T3844-YJ)

Name: Mouse Anti-TPMT Recombinant Antibody (CBYJT-4356)
SKU: CBMAB-T3844-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4356

Application

ELISA, WB

Immunogen

Recombinant protein corresponding to aa1-245 from human TPMT expressed in E. coli

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 10% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-245

More Infomation

Target

Full Name

thiopurine S-methyltransferase

Introduction

TPMT is the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency.

Entrez Gene ID

7172

UniProt ID

P51580

Alternative Names

Thiopurine S-Methyltransferase; EC 2.1.1.67; S-Adenosyl-L-Methionine:Thiopurine S-Methyltransferase; Thiopurine Methyltransferase; TPMTD

Function

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748).
TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.

Biological Process

Biological Process methylation Source:Reactome
Biological Process nucleobase-containing compound metabolic process Source:ProtInc1 Publication
Biological Process xenobiotic catabolic process Source:Reactome
Biological Process xenobiotic metabolic process Source:UniProtKB2 Publications

Cellular Location

Cytoplasm

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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