TPMT

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq]
Full Name
thiopurine S-methyltransferase
Function
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748).
TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.
Biological Process
Biological Process methylation Source:Reactome
Biological Process nucleobase-containing compound metabolic process Source:ProtInc1 Publication
Biological Process xenobiotic catabolic process Source:Reactome
Biological Process xenobiotic metabolic process Source:UniProtKB2 Publications
Cellular Location
Cytoplasm
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Anti-TPMT antibodies

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Mouse Anti-TPMT Recombinant Antibody (2H3) (CBMAB-A9459-LY)

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Target: TPMT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H3
Application*: WB, E
Datasheet SDS

Mouse Anti-TPMT Recombinant Antibody (1D4) (CBMAB-A9458-LY)

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Target: TPMT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D4
Application*: WB, E
Datasheet SDS

Mouse Anti-TPMT Recombinant Antibody (1B5) (CBMAB-A9457-LY)

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Target: TPMT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1B5
Application*: WB, E
Datasheet SDS

Rabbit Anti-TPMT Recombinant Antibody (CBYJT-4365) (CBMAB-T3854-YJ)

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Target: TPMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-4365
Application*: WB, IP, P, IC, F
Datasheet SDS

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4364) (CBMAB-T3853-YJ)

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Target: TPMT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: CBYJT-4364
Application*: F, IH, P, WB
Datasheet SDS

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4363) (CBMAB-T3852-YJ)

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Target: TPMT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4363
Application*: SE, E, WB
Datasheet SDS

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4362) (CBMAB-T3850-YJ)

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Target: TPMT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4362
Application*: IH, WB
Datasheet SDS

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4361) (CBMAB-T3849-YJ)

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Target: TPMT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4361
Application*: IH, P, WB
Datasheet SDS

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4360) (CBMAB-T3848-YJ)

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Target: TPMT
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4360
Application*: E, WB
Datasheet SDS

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4359) (CBMAB-T3847-YJ)

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Target: TPMT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4359
Application*: WB, E
Datasheet SDS

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4358) (CBMAB-T3846-YJ)

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Target: TPMT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4358
Application*: IC, IF, IH, P, WB
Datasheet SDS

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4357) (CBMAB-T3845-YJ)

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Target: TPMT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4357
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4356) (CBMAB-T3844-YJ)

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Target: TPMT
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4356
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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