TPMT

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq]

Full Name

thiopurine S-methyltransferase

Function

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748).
TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.

Biological Process

Biological Process methylation Source:Reactome
Biological Process nucleobase-containing compound metabolic process Source:ProtInc1 Publication
Biological Process xenobiotic catabolic process Source:Reactome
Biological Process xenobiotic metabolic process Source:UniProtKB2 Publications

Cellular Location

Cytoplasm

Anti-TPMT antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-TPMT Recombinant Antibody (2H3) (CBMAB-A9459-LY)

Datasheet

SDS

Target: TPMT

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2H3

Application*: WB, E

Mouse Anti-TPMT Recombinant Antibody (1D4) (CBMAB-A9458-LY)

Datasheet

SDS

Target: TPMT

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1D4

Application*: WB, E

Mouse Anti-TPMT Recombinant Antibody (1B5) (CBMAB-A9457-LY)

Datasheet

SDS

Target: TPMT

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1B5

Application*: WB, E

Rabbit Anti-TPMT Recombinant Antibody (CBYJT-4365) (CBMAB-T3854-YJ)

Datasheet

SDS

Target: TPMT

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Rat, Mouse

Clone: CBYJT-4365

Application*: WB, IP, P, IC, F

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4364) (CBMAB-T3853-YJ)

Datasheet

SDS

Target: TPMT

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog

Clone: CBYJT-4364

Application*: F, IH, P, WB

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4363) (CBMAB-T3852-YJ)

Datasheet

SDS

Target: TPMT

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4363

Application*: SE, E, WB

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4362) (CBMAB-T3850-YJ)

Datasheet

SDS

Target: TPMT

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4362

Application*: IH, WB

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4361) (CBMAB-T3849-YJ)

Datasheet

SDS

Target: TPMT

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4361

Application*: IH, P, WB

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4360) (CBMAB-T3848-YJ)

Datasheet

SDS

Target: TPMT

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-4360

Application*: E, WB

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4359) (CBMAB-T3847-YJ)

Datasheet

SDS

Target: TPMT

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4359

Application*: WB, E

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4358) (CBMAB-T3846-YJ)

Datasheet

SDS

Target: TPMT

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4358

Application*: IC, IF, IH, P, WB

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4357) (CBMAB-T3845-YJ)

Datasheet

SDS

Target: TPMT

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4357

Application*: E, IF, IH, WB

Mouse Anti-TPMT Recombinant Antibody (CBYJT-4356) (CBMAB-T3844-YJ)

Datasheet

SDS

Target: TPMT

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-4356

Application*: E, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)