Mouse Anti-TRA Recombinant Antibody (CBYJT-4457) (CBMAB-T3957-YJ)

Name: Mouse Anti-TRA Recombinant Antibody (CBYJT-4457)
SKU: CBMAB-T3957-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4457

Application

Immunogen

Recombinant TCR

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2, BSA

Preservative

0.09% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

T cell receptor alpha locus

Introduction

Diseases associated with TRA include Precursor T-Cell Acute Lymphoblastic Leukemia and Hypersomnia. Among its related pathways are G-protein signaling N-RAS regulation pathway and T-Cell Receptor and Co-stimulatory Signaling.

Entrez Gene ID

6955

UniProt ID

P0DTU3

Alternative Names

T Cell Receptor Alpha Locus; TCRA, TRA@; T-Cell Antigen Receptor, Alpha Polypeptide; T-Cell Receptor, Alpha (V, D, J, C); TRAC; IMD7; TCRD; TCRA; TRA@

Function

The alpha chain of TRAV38-2DV8*01J31*01C*01/TRBV25-1*01J2S3*01C2*01 alpha-beta T cell receptor (TR) clonotype that displays pan-cancer cell recognition via the invariant MR1 molecule. On CD8-positive T cell clone MC.7.G5, likely recognizes tumor-specific or -associated metabolite(s) essential for cancer cell survival, triggering killing of many cancer cell types including lung, melanoma, leukemia, colon, breast, prostate, bone and ovarian cancer cells. Mediates cancer cell cytotoxicity in an HLA-independent manner. Has no reactivity to healthy cells, even stressed or infected by bacteria (PubMed:31959982).
Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity).

Biological Process

Biological Process detection of tumor cell Source:UniProtKB1 Publication
Biological Process T cell mediated cytotoxicity directed against tumor cell target Source:UniProtKB1 Publication

Cellular Location

Cell membrane

Topology

Helical: 251-273
Cytoplasmic: 274-275

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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