TRA
Diseases associated with TRA include Precursor T-Cell Acute Lymphoblastic Leukemia and Hypersomnia. Among its related pathways are G-protein signaling N-RAS regulation pathway and T-Cell Receptor and Co-stimulatory Signaling.
Full Name
T cell receptor alpha locus
Function
The alpha chain of TRAV38-2DV8*01J31*01C*01/TRBV25-1*01J2S3*01C2*01 alpha-beta T cell receptor (TR) clonotype that displays pan-cancer cell recognition via the invariant MR1 molecule. On CD8-positive T cell clone MC.7.G5, likely recognizes tumor-specific or -associated metabolite(s) essential for cancer cell survival, triggering killing of many cancer cell types including lung, melanoma, leukemia, colon, breast, prostate, bone and ovarian cancer cells. Mediates cancer cell cytotoxicity in an HLA-independent manner. Has no reactivity to healthy cells, even stressed or infected by bacteria (PubMed:31959982).
Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity).
Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity).
Biological Process
Biological Process detection of tumor cell Source:UniProtKB1 Publication
Biological Process T cell mediated cytotoxicity directed against tumor cell target Source:UniProtKB1 Publication
Biological Process T cell mediated cytotoxicity directed against tumor cell target Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Helical: 251-273
Cytoplasmic: 274-275
Cytoplasmic: 274-275
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Anti-TRA antibodies
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CompareTarget: TRA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 6D6.6
Application*: B, F, IH, C, IP, WB, A
Target: TRA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4460
Application*: WB, IP, IF, E
Target: TRA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-4459
Application*: E, WB
Target: TRA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4458
Application*: IH, IP
Target: TRA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4457
Application*: F
Target: TRA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4456
Application*: F, C, P, IP
Target: TRA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4455
Application*: WB, F, E, MC
Target: TRA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4454
Application*: WB, F, E, MC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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