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Mouse Anti-TRAF3IP3 Recombinant Antibody (7E10) (CBMAB-A9477-LY)

The product is antibody recognizes TRAF3IP3. The antibody 7E10 immunoassay techniques such as: WB, ELISA.
See all TRAF3IP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7E10
Antibody Isotype
IgG2a, λ
Application
WB, ELISA

Basic Information

Immunogen
TRAF3IP3 (NP_079504.1, 231 a.a. ~ 330 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TRAF3 interacting protein 3
Entrez Gene ID
80342
UniProt ID
Q9Y228
Alternative Names
DJ434O14.3; FLJ44151; MGC117354; MGC163289; T3JAM
Function
Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727).
Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727).
Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741).
Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680).
In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091).
However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (PubMed:32366851).
Cellular Location
Cell membrane
Golgi apparatus membrane
Lysosome membrane
Mitochondrion outer membrane
Accumulates on the mitochondria after virus infection.
Topology
Cytoplasmic: 1-526
Helical: 527-544
Extracellular: 545-551
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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