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Mouse Anti-TRAF3IP3 Recombinant Antibody (CBYJT-4513) (CBMAB-T4018-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRAF3IP3 (TRAF3 Interacting Protein 3). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TRAF3IP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4513
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TRAF3 interacting protein 3
Introduction
TRAF3IP3 is a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. TRAF3IP3 may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit.
Entrez Gene ID
80342
UniProt ID
Q9Y228
Alternative Names
TRAF3 Interacting Protein 3; TRAF3 Interacting Jun N Terminal Kinase (JNK) Activating Modulator; T3JAM; TRAF3-Interacting JNK-Activating Modulator; TRAF3-Interacting Protein 3
Function
Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727).
Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727).
Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741).
Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680).
In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091).
However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (PubMed:32366851).
Cellular Location
Cell membrane
Golgi apparatus membrane
Lysosome membrane
Mitochondrion outer membrane
Accumulates on the mitochondria after virus infection.
Topology
Cytoplasmic: 1-526
Helical: 527-544
Extracellular: 545-551
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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