Mouse Anti-TRAM2 Recombinant Antibody (3G6) (CBMAB-A9480-LY)

Name: Mouse Anti-TRAM2 Recombinant Antibody (3G6)
SKU: CBMAB-A9480-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3G6

Application

WB, ELISA

Immunogen

TRAM2 (NP_036420, 310 a.a. ~ 369 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

translocation associated membrane protein 2

Introduction

TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM

Entrez Gene ID

9697

UniProt ID

Q15035

Alternative Names

KIAA0057

Function

Necessary for collagen type I synthesis. May couple the activity of the ER Ca2+ pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca2+ concentration at the site of collagen synthesis, and a high Ca2+ concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293).

Biological Process

Biological Process collagen biosynthetic process Source:UniProtKB1 Publication
Biological Process protein insertion into ER membrane Source:UniProtKB1 Publication
Biological Process SRP-dependent cotranslational protein targeting to membrane, translocation Source:InterPro

Cellular Location

Membrane

Topology

Cytoplasmic: 1-22
Helical: 23-43
Extracellular: 44-75
Helical: 76-96
Cytoplasmic: 97-119
Helical: 120-140
Extracellular: 141-159
Helical: 160-180
Cytoplasmic: 181-191
Helical: 192-209
Extracellular: 210-214
Helical: 215-235
Cytoplasmic: 236-250
Helical: 251-271
Extracellular: 272-287
Helical: 288-308
Cytoplasmic: 309-370

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-TRAM2 Recombinant Antibody (CBYJT-4543) (CAT#: CBMAB-T4052-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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