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Mouse Anti-TRAM2 Recombinant Antibody (3G6) (CBMAB-A9480-LY)

The product is antibody recognizes TRAM2. The antibody 3G6 immunoassay techniques such as: WB, ELISA.
See all TRAM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G6
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
TRAM2 (NP_036420, 310 a.a. ~ 369 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
translocation associated membrane protein 2
Introduction
TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM
Entrez Gene ID
9697
UniProt ID
Q15035
Alternative Names
KIAA0057
Function
Necessary for collagen type I synthesis. May couple the activity of the ER Ca2+ pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca2+ concentration at the site of collagen synthesis, and a high Ca2+ concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293).
Biological Process
Biological Process collagen biosynthetic process Source:UniProtKB1 Publication
Biological Process protein insertion into ER membrane Source:UniProtKB1 Publication
Biological Process SRP-dependent cotranslational protein targeting to membrane, translocation Source:InterPro
Cellular Location
Membrane
Topology
Cytoplasmic: 1-22
Helical: 23-43
Extracellular: 44-75
Helical: 76-96
Cytoplasmic: 97-119
Helical: 120-140
Extracellular: 141-159
Helical: 160-180
Cytoplasmic: 181-191
Helical: 192-209
Extracellular: 210-214
Helical: 215-235
Cytoplasmic: 236-250
Helical: 251-271
Extracellular: 272-287
Helical: 288-308
Cytoplasmic: 309-370
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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