TRAM2

TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM

Full Name

translocation associated membrane protein 2

Function

Necessary for collagen type I synthesis. May couple the activity of the ER Ca2+ pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca2+ concentration at the site of collagen synthesis, and a high Ca2+ concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293).

Biological Process

Biological Process collagen biosynthetic process Source:UniProtKB1 Publication
Biological Process protein insertion into ER membrane Source:UniProtKB1 Publication
Biological Process SRP-dependent cotranslational protein targeting to membrane, translocation Source:InterPro

Cellular Location

Membrane

Topology

Cytoplasmic: 1-22
Helical: 23-43
Extracellular: 44-75
Helical: 76-96
Cytoplasmic: 97-119
Helical: 120-140
Extracellular: 141-159
Helical: 160-180
Cytoplasmic: 181-191
Helical: 192-209
Extracellular: 210-214
Helical: 215-235
Cytoplasmic: 236-250
Helical: 251-271
Extracellular: 272-287
Helical: 288-308
Cytoplasmic: 309-370