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Mouse Anti-TRAT1 Recombinant Antibody (TRIM-04) (CBMAB-T4087-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRAT1 (T Cell Receptor Associated Transmembrane Adaptor 1). The antibody can be used for immunoassay techniques, such as WB, FC, IP, CyTOF.
See all TRAT1 antibodies
Published Data
Fig.1 Lysates and immunoprecipitated material from the procedure were immunoblotted with antibodies against Lat, Trat1, Grb2, Itch, Cbl-b, Wdr20, Wdr48, and Usp46 to confirm the mass spectroscopy hits.
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Fig.2 Immunoblots against pLAT, LAT, Trat1, pSLP-76, and SLP-76 in control and Usp12−/− cells.
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Fig.3 LAT and Trat1 were immunoprecipitated from WT and Usp12−/− cells expressing HA-Ub and stimulated with anti-CD3.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
TRIM-04
Antibody Isotype
IgG2a
Application
WB, FC, IP, CyTOF

Basic Information

Immunogen
Recombinant fragment, corresponding to amino acids 29-186 of Human TRIM
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 29-186

Target

Full Name
T Cell Receptor Associated Transmembrane Adaptor 1
Introduction
TRAT1 (T Cell Receptor Associated Transmembrane Adaptor 1) is a Protein Coding gene. Among its related pathways are RET signaling and Innate Immune System. Gene Ontology (GO) annotations related to TRAT1 include transmembrane receptor protein tyrosine kinase adaptor activity.
Entrez Gene ID
50852
UniProt ID
Q6PIZ9
Alternative Names
T Cell Receptor Associated Transmembrane Adaptor 1; TCRIM; Pp29/30; TRIM; T-Cell Receptor-Associated Transmembrane Adapter 1; T-Cell Receptor Associated Transmembrane Adaptor 1; T Cell Receptor Interacting Molecule; T-Cell Receptor-Interacting Molecule; HSPC062
Function
Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process cellular defense response Source:ProtInc1 Publication
Biological Process negative regulation of receptor recycling Source:MGI1 Publication
Biological Process negative regulation of transport Source:MGI1 Publication
Biological Process positive regulation of calcium-mediated signaling Source:MGI1 Publication
Biological Process positive regulation of T cell receptor signaling pathway Source:MGI1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 1-7
Helical: 8-28
Cytoplasmic: 29-186
PTM
Phosphorylated on tyrosines by LCK or FYN upon TCR activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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