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TRAT1

TRAT1 (T Cell Receptor Associated Transmembrane Adaptor 1) is a Protein Coding gene. Among its related pathways are RET signaling and Innate Immune System. Gene Ontology (GO) annotations related to TRAT1 include transmembrane receptor protein tyrosine kinase adaptor activity.

Full Name

T Cell Receptor Associated Transmembrane Adaptor 1

Function

Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.

Biological Process

Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process cellular defense response Source:ProtInc1 Publication
Biological Process negative regulation of receptor recycling Source:MGI1 Publication
Biological Process negative regulation of transport Source:MGI1 Publication
Biological Process positive regulation of calcium-mediated signaling Source:MGI1 Publication
Biological Process positive regulation of T cell receptor signaling pathway Source:MGI1 Publication
Biological Process signal transduction Source:ProtInc1 Publication

Cellular Location

Cell membrane

Topology

Extracellular: 1-7
Helical: 8-28
Cytoplasmic: 29-186

PTM

Phosphorylated on tyrosines by LCK or FYN upon TCR activation.

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Anti-TRAT1 antibodies

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Mouse Anti-TRAT1 Recombinant Antibody (CBYJT-4572) (CBMAB-T4085-YJ)

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Target: TRAT1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4572

Application*: WB, IS

Mouse Anti-TRAT1 Recombinant Antibody (TRIM-04) (CBMAB-T4087-YJ)

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Target: TRAT1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: TRIM-04

Application*: WB, F, IP, MC

Mouse Anti-TRAT1 Recombinant Antibody (CBYJT-4573) (CBMAB-T4086-YJ)

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Target: TRAT1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4573

Application*: F, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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