Mouse Anti-TRIM16 Recombinant Antibody (CBYJT-4682) (CBMAB-T4218-YJ)

Name: Mouse Anti-TRIM16 Recombinant Antibody (CBYJT-4682)
SKU: CBMAB-T4218-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4682

Application

ELISA, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TRIM16 Gene(Protein Coding) Tripartite Motif Containing 16

Introduction

TRIM16 is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, TRIM16 can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity.

Entrez Gene ID

10626

UniProt ID

O95361

Alternative Names

Tripartite Motif Containing 16; Estrogen-Responsive B Box Protein; EBBP; Tripartite Motif-Containing Protein 16; Tripartite Motif-Containing 16

Function

E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.

Biological Process

Biological Process histone H3 acetylation Source:UniProtKB1 Publication
Biological Process histone H4 acetylation Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB2 Publications
Biological Process positive regulation of interleukin-1 beta production Source:UniProtKB1 Publication
Biological Process positive regulation of keratinocyte differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of retinoic acid receptor signaling pathway Source:UniProtKB1 Publication
Biological Process response to growth hormone Source:UniProtKB1 Publication
Biological Process response to organophosphorus Source:UniProtKB1 Publication
Biological Process response to retinoic acid Source:UniProtKB1 Publication

Cellular Location

Cytoplasm

PTM

Phosphorylated by ULK1.
Auto-ubiquitinates via its B-Boxes.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TRIM16 Matched Antibody Pair (1273) (CAT#: APMAB-1273LY)

Related Products

Mouse Anti-TRIM16 Recombinant Antibody (CBYJT-4681) (CAT#: CBMAB-T4217-YJ)

Mouse Anti-TRIM16 Recombinant Antibody (CBYJT-4684) (CAT#: CBMAB-T4220-YJ)

TRIM16 Matched Antibody Pair (1273) (CAT#: APMAB-1273LY)

Mouse Anti-TRIM16 Recombinant Antibody (CBYJT-4683) (CAT#: CBMAB-T4219-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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