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Mouse Anti-TRIM16 Recombinant Antibody (CBYJT-4684) (CBMAB-T4220-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIM16 (Tripartite Motif Containing 16). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TRIM16 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
CBYJT-4684
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Specific for an epitope mapping between amino acids 181-206 within an internal region of TRIM16 of human origin
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 181-206

Target

Full Name
TRIM16 Gene(Protein Coding) Tripartite Motif Containing 16
Introduction
TRIM16 is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, TRIM16 can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity.
Entrez Gene ID
Human10626
Mouse94092
Rat303214
UniProt ID
HumanO95361
MouseQ99PP9
RatD3ZW47
Alternative Names
Tripartite Motif Containing 16; Estrogen-Responsive B Box Protein; EBBP; Tripartite Motif-Containing Protein 16; Tripartite Motif-Containing 16
Function
E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.
Biological Process
Biological Process histone H3 acetylation Source:UniProtKB1 Publication
Biological Process histone H4 acetylation Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB2 Publications
Biological Process positive regulation of interleukin-1 beta production Source:UniProtKB1 Publication
Biological Process positive regulation of keratinocyte differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of retinoic acid receptor signaling pathway Source:UniProtKB1 Publication
Biological Process response to growth hormone Source:UniProtKB1 Publication
Biological Process response to organophosphorus Source:UniProtKB1 Publication
Biological Process response to retinoic acid Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
PTM
Phosphorylated by ULK1.
Auto-ubiquitinates via its B-Boxes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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