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Mouse Anti-TRIM37 Recombinant Antibody (CBYJT-4761) (CBMAB-T4302-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIM37 (Tripartite Motif Containing 37). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TRIM37 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4761
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa865-964 from human TRIM37 (NP_056109) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 865-964

Target

Full Name
TRIM37 Gene(Protein Coding) Tripartite Motif Containing 37
Introduction
TRIM37 is a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. TRIM37 mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin.
Entrez Gene ID
4591
UniProt ID
O94972
Alternative Names
Tripartite Motif Containing 37; RING-Type E3 Ubiquitin Transferase TRIM37; RING-B-Box-Coiled-Coil Protein; Mulibrey Nanism Protein; POB1; MUL; Tripartite Motif-Containing Protein 37
Function
E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972).
Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972).
Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042).
Has anti-HIV activity (PubMed:24317724).
Biological Process
Biological Process aggresome assembly Source:UniProtKB1 Publication
Biological Process histone H2A monoubiquitination Source:UniProtKB1 Publication
Biological Process histone H2A-K119 monoubiquitination Source:UniProtKB1 Publication
Biological Process negative regulation of centriole replication Source:UniProtKB1 Publication
Biological Process negative regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process protein autoubiquitination Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, perinuclear region
Peroxisome
Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.
Involvement in disease
Mulibrey nanism (MUL):
An autosomal recessive growth disorder characterized by severe growth failure of prenatal onset, constrictive pericardium and progressive cardiomyopathy, facial dysmorphism, and failure of sexual maturation. Additional clinical features include hepatomegaly, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, hypoplasia of various endocrine glands, insulin resistance with type 2 diabetes, and an increased risk for Wilms' tumor.
PTM
Auto-ubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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