Human Recombinant TRIM37, Active protein, GST Tag (V2LY-0526-LY7379)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972).
Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042).
Has anti-HIV activity (PubMed:24317724).
Biological Process histone H2A monoubiquitination Source:UniProtKB1 Publication
Biological Process histone H2A-K119 monoubiquitination Source:UniProtKB1 Publication
Biological Process negative regulation of centriole replication Source:UniProtKB1 Publication
Biological Process negative regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process protein autoubiquitination Source:UniProtKB1 Publication
Peroxisome
Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.
An autosomal recessive growth disorder characterized by severe growth failure of prenatal onset, constrictive pericardium and progressive cardiomyopathy, facial dysmorphism, and failure of sexual maturation. Additional clinical features include hepatomegaly, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, hypoplasia of various endocrine glands, insulin resistance with type 2 diabetes, and an increased risk for Wilms' tumor.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Rabbit Anti-TRIM37 Recombinant Antibody (D7U2L) (CAT#: CBMAB-CP2866-LY)
Mouse Anti-TRIM37 Recombinant Antibody (CBYJT-4761) (CAT#: CBMAB-T4302-YJ)
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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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