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Mouse Anti-TRIM38 Recombinant Antibody (CBYJT-4764) (CBMAB-T4305-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIM38 (Tripartite Motif Containing 38). The antibody can be used for immunoassay techniques, such as WB, IHC, IF.
See all TRIM38 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4764
Antibody Isotype
IgG1
Application
WB, IHC, IF

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-265 of human TRIM38(NP_006346) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-265

Target

Full Name
Tripartite Motif Containing 38
Introduction
TRIM38 is a member of the tripartite motif (TRIM) family. TRIM38 contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of TRIM38 has not been identified.
Entrez Gene ID
10475
UniProt ID
O00635
Alternative Names
Tripartite Motif Containing 38; RING-Type E3 Ubiquitin Transferase TRIM38; Tripartite Motif-Containing Protein 38; Zinc Finger Protein RoRet; Ring Finger Protein 15; RNF15; RORET
Function
E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:23056470).
Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity).
Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:23056470).
Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity).
Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (PubMed:24434549).
Biological Process
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process negative regulation of defense response to virus Source:Ensembl
Biological Process positive regulation of autophagy Source:GO_Central1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of viral entry into host cell Source:UniProtKB1 Publication
Biological Process positive regulation of viral genome replication Source:Ensembl
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:Ensembl
Biological Process protein K48-linked ubiquitination Source:Ensembl
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process protein sumoylation Source:UniProtKB-UniPathway
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of interferon-beta production Source:Ensembl
Biological Process regulation of protein localization Source:GO_Central1 Publication
Biological Process regulation of viral entry into host cell Source:GO_Central1 Publication
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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