TRIM38
TRIM38 is a member of the tripartite motif (TRIM) family. TRIM38 contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of TRIM38 has not been identified.
Full Name
Tripartite Motif Containing 38
Function
E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:23056470).
Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity).
Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:23056470).
Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity).
Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (PubMed:24434549).
Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity).
Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:23056470).
Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity).
Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (PubMed:24434549).
Biological Process
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process negative regulation of defense response to virus Source:Ensembl
Biological Process positive regulation of autophagy Source:GO_Central1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of viral entry into host cell Source:UniProtKB1 Publication
Biological Process positive regulation of viral genome replication Source:Ensembl
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:Ensembl
Biological Process protein K48-linked ubiquitination Source:Ensembl
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process protein sumoylation Source:UniProtKB-UniPathway
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of interferon-beta production Source:Ensembl
Biological Process regulation of protein localization Source:GO_Central1 Publication
Biological Process regulation of viral entry into host cell Source:GO_Central1 Publication
Biological Process negative regulation of defense response to virus Source:Ensembl
Biological Process positive regulation of autophagy Source:GO_Central1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of viral entry into host cell Source:UniProtKB1 Publication
Biological Process positive regulation of viral genome replication Source:Ensembl
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:Ensembl
Biological Process protein K48-linked ubiquitination Source:Ensembl
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process protein sumoylation Source:UniProtKB-UniPathway
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of interferon-beta production Source:Ensembl
Biological Process regulation of protein localization Source:GO_Central1 Publication
Biological Process regulation of viral entry into host cell Source:GO_Central1 Publication
Cellular Location
Cytoplasm
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Anti-TRIM38 antibodies
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CompareTarget: TRIM38
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse
Clone: CBYJT-4777
Application*: WB
Target: TRIM38
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse
Clone: CBYJT-4776
Application*: WB, IF
Target: TRIM38
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBYJT-4775
Application*: WB, IH, IF
Target: TRIM38
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBYJT-4774
Application*: WB, IH
Target: TRIM38
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: CBYJT-4773
Application*: WB, IH
Target: TRIM38
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: CBYJT-4772
Application*: WB, IH, IF
Target: TRIM38
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: CBYJT-4771
Application*: WB, IH, IF
Target: TRIM38
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4770
Application*: IH
Target: TRIM38
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4769
Application*: WB
Target: TRIM38
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4768
Application*: WB, IH
Target: TRIM38
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4767
Application*: WB, IH
Target: TRIM38
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4766
Application*: WB, IH, IF
Target: TRIM38
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4765
Application*: IF, P, WB
Target: TRIM38
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4764
Application*: WB, IH, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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