TRIM38

TRIM38 is a member of the tripartite motif (TRIM) family. TRIM38 contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of TRIM38 has not been identified.

Tripartite Motif Containing 38

E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:23056470).
Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity).
Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:23056470).
Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity).
Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (PubMed:24434549).

Biological Process innate immune response Source:GO_Central1 Publication
Biological Process negative regulation of defense response to virus Source:Ensembl
Biological Process positive regulation of autophagy Source:GO_Central1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of viral entry into host cell Source:UniProtKB1 Publication
Biological Process positive regulation of viral genome replication Source:Ensembl
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:Ensembl
Biological Process protein K48-linked ubiquitination Source:Ensembl
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process protein sumoylation Source:UniProtKB-UniPathway
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of interferon-beta production Source:Ensembl
Biological Process regulation of protein localization Source:GO_Central1 Publication
Biological Process regulation of viral entry into host cell Source:GO_Central1 Publication

Cytoplasm