Mouse Anti-TRIM39 Recombinant Antibody (CBYJT-4778) (CBMAB-T4319-YJ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
E3 ubiquitin-protein ligase (PubMed:22529100).
May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100).
Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251).
Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).
Isoform 2
Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251).
Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).
Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner (PubMed:26363554).
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process mitotic G2 DNA damage checkpoint signaling Source:UniProtKB1 Publication
Biological Process negative regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process negative regulation of ubiquitin-dependent protein catabolic process Source:BHF-UCL1 Publication
Biological Process positive regulation of apoptotic signaling pathway Source:BHF-UCL1 Publication
Biological Process protein stabilization Source:UniProtKB2 Publications
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of cell cycle G1/S phase transition Source:UniProtKB1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Cytoplasm, cytosol
Mitochondrion
Nucleus
Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus.
Isoform 2
Nucleus
Colocalizes with CDKN1A in the nucleus.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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