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Mouse Anti-TRIM39 Recombinant Antibody (CBYJT-4778) (CBMAB-T4319-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIM39 (Tripartite Motif Containing 39). The antibody can be used for immunoassay techniques, such as WB.
See all TRIM39 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4778
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 144-378 of human TRIM39 (NP_742013) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 144-378

Target

Full Name
Tripartite Motif Containing 39
Introduction
TRIM39 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of it has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6.
Entrez Gene ID
56658
UniProt ID
Q9HCM9
Alternative Names
Tripartite Motif Containing 39; RING-Type E3 Ubiquitin Transferase TRIM39; Tripartite Motif-Containing Protein 39; Testis-Abundant Finger Protein; Ring Finger Protein 23; RNF23; TFP
Function
Isoform 1
E3 ubiquitin-protein ligase (PubMed:22529100).
May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100).
Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251).
Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).
Isoform 2
Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251).
Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).
Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner (PubMed:26363554).
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process mitotic G2 DNA damage checkpoint signaling Source:UniProtKB1 Publication
Biological Process negative regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process negative regulation of ubiquitin-dependent protein catabolic process Source:BHF-UCL1 Publication
Biological Process positive regulation of apoptotic signaling pathway Source:BHF-UCL1 Publication
Biological Process protein stabilization Source:UniProtKB2 Publications
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of cell cycle G1/S phase transition Source:UniProtKB1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Cellular Location
Isoform 1
Cytoplasm, cytosol
Mitochondrion
Nucleus
Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus.
Isoform 2
Nucleus
Colocalizes with CDKN1A in the nucleus.
PTM
Autoubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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