TRIM39

TRIM39 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of it has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6.

Full Name

Tripartite Motif Containing 39

Function

Isoform 1
E3 ubiquitin-protein ligase (PubMed:22529100).
May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100).
Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251).
Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).
Isoform 2
Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251).
Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).
Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner (PubMed:26363554).

Biological Process

Biological Process apoptotic process Source:UniProtKB-KW
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process mitotic G2 DNA damage checkpoint signaling Source:UniProtKB1 Publication
Biological Process negative regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process negative regulation of ubiquitin-dependent protein catabolic process Source:BHF-UCL1 Publication
Biological Process positive regulation of apoptotic signaling pathway Source:BHF-UCL1 Publication
Biological Process protein stabilization Source:UniProtKB2 Publications
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of cell cycle G1/S phase transition Source:UniProtKB1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication

Cellular Location

Isoform 1
Cytoplasm, cytosol
Mitochondrion
Nucleus
Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus.
Isoform 2
Nucleus
Colocalizes with CDKN1A in the nucleus.

PTM

Autoubiquitinated.