Mouse Anti-TRIM62 Recombinant Antibody (4A4) (CBMAB-A9533-LY)

Name: Mouse Anti-TRIM62 Recombinant Antibody (4A4)
SKU: CBMAB-A9533-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4A4

Application

sELISA, ELISA

Immunogen

TRIM62 (NP_060677, 376 a.a. ~ 475 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

tripartite motif-containing 62

Entrez Gene ID

55223

UniProt ID

Q9BVG3

Alternative Names

FLJ10759; FLJ16558

Function

E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:26488816).
E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (PubMed:23402750).

Biological Process

Biological Process innate immune response Source:UniProtKB1 Publication
Biological Process negative regulation of epithelial to mesenchymal transition Source:Ensembl
Biological Process negative regulation of viral transcription Source:UniProtKB1 Publication
Biological Process positive regulation of antifungal innate immune response Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process protein K27-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of viral entry into host cell Source:UniProtKB1 Publication
Biological Process viral release from host cell Source:UniProtKB1 Publication

Cellular Location

Cytoplasm

PTM

Polyubiquitinated, autoubiquitinated in the presence of UBE2D2.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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