TRIM62

TRIM62 (Tripartite Motif Containing 62) is a Protein Coding gene. Diseases associated with TRIM62 include Ring Chromosome 1. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM69.

Full Name

tripartite motif-containing 62

Function

E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:26488816).
E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (PubMed:23402750).

Biological Process

Biological Process innate immune response Source:UniProtKB1 Publication
Biological Process negative regulation of epithelial to mesenchymal transition Source:Ensembl
Biological Process negative regulation of viral transcription Source:UniProtKB1 Publication
Biological Process positive regulation of antifungal innate immune response Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process protein K27-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of viral entry into host cell Source:UniProtKB1 Publication
Biological Process viral release from host cell Source:UniProtKB1 Publication

Cellular Location

Cytoplasm

PTM

Polyubiquitinated, autoubiquitinated in the presence of UBE2D2.