Mouse Anti-TRIP13 Recombinant Antibody (CBYJT-4853) (CBMAB-T4398-YJ)

Name: Mouse Anti-TRIP13 Recombinant Antibody (CBYJT-4853)
SKU: CBMAB-T4398-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4853

Application

WB, IHC

Immunogen

Human recombinant protein fragment corresponding to amino acids 31-148 of human TRIP13(NP_001159732) produced in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 31-148

More Infomation

Target

Full Name

thyroid hormone receptor interactor 13

Introduction

TRIP13 is a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. TRIP13 interacts specifically with the ligand binding domain. TRIP13 is one of several that may function in early-stage non-small cell lung cancer.

Entrez Gene ID

9319

UniProt ID

Q15645

Alternative Names

Thyroid Hormone Receptor Interactor 13; Human Papillomavirus Type 16 E1 Protein-Binding Protein; Thyroid Receptor-Interacting Protein 13; TR-Interacting Protein 13; 16E1-BP; TRIP-13; Thyroid Receptor Interacting Protein 13; Pachytene Checkpoint Protein 2 Homolog

Function

Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).
Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959).

Biological Process

Biological Process double-strand break repair Source:UniProtKB
Biological Process female meiosis I Source:Ensembl
Biological Process male meiosis I Source:Ensembl
Biological Process meiotic recombination checkpoint signaling Source:GO_Central1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:UniProtKB1 Publication
Biological Process oocyte maturation Source:Ensembl
Biological Process oogenesis Source:UniProtKB
Biological Process reciprocal meiotic recombination Source:UniProtKB
Biological Process spermatid development Source:Ensembl
Biological Process spermatogenesis Source:UniProtKB
Biological Process synaptonemal complex assembly Source:UniProtKB
Biological Process transcription by RNA polymerase II Source:ProtInc1 Publication

Cellular Location

chromosome
male germ cell nucleus
nucleus

Involvement in disease

Mosaic variegated aneuploidy syndrome 3 (MVA3):
A form of mosaic variegated aneuploidy syndrome, a severe disorder characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple different chromosomes and tissues. Affected individuals typically present with severe intrauterine growth retardation and microcephaly. Eye anomalies, mild dysmorphism, variable developmental delay, and a broad spectrum of additional congenital abnormalities and medical conditions may also occur. The risk of malignancy is high, with rhabdomyosarcoma, Wilms tumor and leukemia reported in several cases. MVA3 inheritance is autosomal recessive.
Oocyte maturation defect 9 (OOMD9):
An autosomal recessive infertility disorder due to oocyte meiotic arrest at metaphase I. Abnormal zygotic cleavage has been observed in some patients.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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