Human TRIP13 ELISA Kit (V2LY-0626-LY1908)

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Tested Data
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Basic Information

Sensitivity
0.0059 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
48.6 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
thyroid hormone receptor interactor 13
Function
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).
Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959).
Biological Process
Biological Process double-strand break repair Source:UniProtKB
Biological Process female meiosis I Source:Ensembl
Biological Process male meiosis I Source:Ensembl
Biological Process meiotic recombination checkpoint signaling Source:GO_Central1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:UniProtKB1 Publication
Biological Process oocyte maturation Source:Ensembl
Biological Process oogenesis Source:UniProtKB
Biological Process reciprocal meiotic recombination Source:UniProtKB
Biological Process spermatid development Source:Ensembl
Biological Process spermatogenesis Source:UniProtKB
Biological Process synaptonemal complex assembly Source:UniProtKB
Biological Process transcription by RNA polymerase II Source:ProtInc1 Publication
Cellular Location
chromosome
male germ cell nucleus
nucleus
Involvement in disease
Mosaic variegated aneuploidy syndrome 3 (MVA3):
A form of mosaic variegated aneuploidy syndrome, a severe disorder characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple different chromosomes and tissues. Affected individuals typically present with severe intrauterine growth retardation and microcephaly. Eye anomalies, mild dysmorphism, variable developmental delay, and a broad spectrum of additional congenital abnormalities and medical conditions may also occur. The risk of malignancy is high, with rhabdomyosarcoma, Wilms tumor and leukemia reported in several cases. MVA3 inheritance is autosomal recessive.
Oocyte maturation defect 9 (OOMD9):
An autosomal recessive infertility disorder due to oocyte meiotic arrest at metaphase I. Abnormal zygotic cleavage has been observed in some patients.
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For research use only. Not intended for any clinical use.

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