Mouse Anti-TRUB2 Recombinant Antibody (CBYJT-4935) (CBMAB-T4491-YJ)

Name: Mouse Anti-TRUB2 Recombinant Antibody (CBYJT-4935)
SKU: CBMAB-T4491-YJ
Rating: 5 (1 reviews)

See all TRUB2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-4935

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TruB Pseudouridine Synthase Family Member 2

Introduction

Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).

Entrez Gene ID

26995

UniProt ID

O95900

Alternative Names

TruB Pseudouridine Synthase Family Member 2; TruB Pseudouridine (Psi) Synthase Family Member 2; TruB Pseudouridine (Psi) Synthase Homolog 2 (E. Coli); Mitochondrial MRNA Pseudouridine Synthase TRUB2; TruB Pseudouridine (Psi) Synthase Homolog 2; Probable TRNA Pseudouridine Synthase 2; EC 5.4.99.-; CLONE24922

Function

Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379, PubMed:31477916).
As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664).
Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine55 from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:33023933).

Biological Process

Biological Process mRNA processing Source:UniProtKB-KW
Biological Process mRNA pseudouridine synthesis Source:FlyBase1 Publication
Biological Process positive regulation of mitochondrial translation Source:UniProtKB1 Publication
Biological Process tRNA processing Source:UniProtKB-KW

Cellular Location

Mitochondrion matrix
Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-TRUB2 Recombinant Antibody (CBYJT-4935)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-TRUB2 Recombinant Antibody (CBYJT-4934) (CAT#: CBMAB-T4490-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry