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Mouse Anti-TRUB2 Recombinant Antibody (CBYJT-4935) (CBMAB-T4491-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRUB2 (TruB Pseudouridine Synthase Family Member 2). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TRUB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4935
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TruB Pseudouridine Synthase Family Member 2
Introduction
Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).
Entrez Gene ID
UniProt ID
Alternative Names
TruB Pseudouridine Synthase Family Member 2; TruB Pseudouridine (Psi) Synthase Family Member 2; TruB Pseudouridine (Psi) Synthase Homolog 2 (E. Coli); Mitochondrial MRNA Pseudouridine Synthase TRUB2; TruB Pseudouridine (Psi) Synthase Homolog 2; Probable TRNA Pseudouridine Synthase 2; EC 5.4.99.-; CLONE24922
Function
Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379, PubMed:31477916).
As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664).
Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine55 from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:33023933).
Biological Process
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process mRNA pseudouridine synthesis Source:FlyBase1 Publication
Biological Process positive regulation of mitochondrial translation Source:UniProtKB1 Publication
Biological Process tRNA processing Source:UniProtKB-KW
Cellular Location
Mitochondrion matrix
Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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