TRUB2

Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).

Full Name

TruB Pseudouridine Synthase Family Member 2

Function

Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379, PubMed:31477916).
As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664).
Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine55 from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:33023933).

Biological Process

Biological Process mRNA processing Source:UniProtKB-KW
Biological Process mRNA pseudouridine synthesis Source:FlyBase1 Publication
Biological Process positive regulation of mitochondrial translation Source:UniProtKB1 Publication
Biological Process tRNA processing Source:UniProtKB-KW

Cellular Location

Mitochondrion matrix
Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly.