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Mouse Anti-TSC22D3 Monoclonal Antibody (1G10) (CBMAB-0275-LY)

This product is mouse monoclonal antibody recognizes TSC22D3 of human. The antibody 1G10 immunoassay techniques such as: IP, ELISA.
Host Species
Mouse
Application
IP, ELISA
Immunogen
Recombinant peptide (Full Length)
Antibody Isotype
IgG2c
Specificity
Human
Clone
1G10
Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).
Alternative Name
DIP; DSIPI; GILZ; hDIP; TSC-22R
Entrez Gene ID
UniProt ID
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For research use only. Not intended for any clinical use.
Cat CBMAB-0275-LY
Conjugates
Size
Price $
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Second antibody and isotype control