Mouse Anti-TSC22D3 Monoclonal Antibody (1G10) (CBMAB-0275-LY)

Name: Mouse Anti-TSC22D3 Monoclonal Antibody (1G10)
SKU: CBMAB-0275-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1G10

Application

IP, ELISA

Immunogen

Recombinant peptide (Full Length)

Specificity

Human

Antibody Isotype

IgG2c

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

TSC22D3 Gene(Protein Coding) TSC22 Domain Family Member 3

Introduction

This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).

Entrez Gene ID

1831

UniProt ID

Q99576

Alternative Names

DIP; DSIPI; GILZ; hDIP; TSC-22R

Function

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity).
Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).

Biological Process

Biological Process negative regulation of activation-induced cell death of T cells Source:Ensembl
Biological Process regulation of transcription by RNA polymerase II Source:InterPro
Biological Process response to osmotic stress Source:Ensembl

Cellular Location

Isoform 1
Cytoplasm
Nucleus
Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TSC22D3 Matched Antibody Pair (1281) (CAT#: APMAB-1281LY)

TSC22D3 Matched Antibody Pair (1282) (CAT#: APMAB-1282LY)

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TSC22D3 Matched Antibody Pair (1282) (CAT#: APMAB-1282LY)

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Mouse Anti-TSC22D3 Recombinant Antibody (CBLG1-2460) (CAT#: CBMAB-G6662-LY)

Mouse Anti-TSC22D3 Recombinant Antibody (3A5) (CAT#: CBMAB-G6661-LY)

TSC22D3 Matched Antibody Pair (1281) (CAT#: APMAB-1281LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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