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TSC22D3

This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Full Name
TSC22D3 Gene(Protein Coding) TSC22 Domain Family Member 3
Function
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity).
Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).
Biological Process
Biological Process negative regulation of activation-induced cell death of T cells Source:Ensembl
Biological Process regulation of transcription by RNA polymerase II Source:InterPro
Biological Process response to osmotic stress Source:Ensembl
Cellular Location
Isoform 1
Cytoplasm
Nucleus
Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus (By similarity).
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Anti-TSC22D3 antibodies

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Mouse Anti-TSC22D3 Recombinant Antibody (2B2) (CBMAB-A9561-LY)

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Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B2
Application*: WB, E
Datasheet SDS

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4983) (CBMAB-T4540-YJ)

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Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4983
Application*: WB
Datasheet SDS

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4982) (CBMAB-T4539-YJ)

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Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4982
Application*: IF, WB
Datasheet SDS

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4981) (CBMAB-T4538-YJ)

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Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4981
Application*: E, IF, IH, IP, WB
Datasheet SDS

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4980) (CBMAB-T4537-YJ)

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Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4980
Application*: WB
Datasheet SDS

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4979) (CBMAB-T4536-YJ)

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Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4979
Application*: WB
Datasheet SDS

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4978) (CBMAB-T4535-YJ)

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Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4978
Application*: WB
Datasheet SDS

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4977) (CBMAB-T4534-YJ)

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Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4977
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-TSC22D3 Recombinant Antibody (CBLG1-2461) (CBMAB-G6663-LY)

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Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-2461
Application*: E, WB
Datasheet SDS

Mouse Anti-TSC22D3 Recombinant Antibody (CBLG1-2460) (CBMAB-G6662-LY)

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Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-2460
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-TSC22D3 Recombinant Antibody (3A5) (CBMAB-G6661-LY)

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Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A5
Application*: WB
Datasheet SDS

Rat Anti-TSC22D3 Recombinant Antibody (CFMKG15) (CBMAB-H3891-FY)

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Target: TSC22D3
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CFMKG15
Application*: WB, F
Datasheet SDS

Mouse Anti-TSC22D3 Recombinant Antibody (CBYCD-524) (CBMAB-D2352-YC)

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Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCD-524
Application*: WB, IC, P, C, E
Datasheet SDS

TSC22D3 Matched Antibody Pair (1282) (APMAB-1282LY)

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Target: TSC22D3
Specificity: Human
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TSC22D3 Matched Antibody Pair (1281) (APMAB-1281LY)

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Target: TSC22D3
Specificity: Human
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Mouse Anti-TSC22D3 Monoclonal Antibody (1G10) (CBMAB-0275-LY)

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Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 1G10
Application*: IP, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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