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TSC22D3

This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Full Name
TSC22D3 Gene(Protein Coding) TSC22 Domain Family Member 3
Function
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity).
Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).
Biological Process
Biological Process negative regulation of activation-induced cell death of T cells Source:Ensembl
Biological Process regulation of transcription by RNA polymerase II Source:InterPro
Biological Process response to osmotic stress Source:Ensembl
Cellular Location
Isoform 1
Cytoplasm
Nucleus
Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus (By similarity).

Anti-TSC22D3 antibodies

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Mouse Anti-TSC22D3 Recombinant Antibody (3A5) (CBMAB-G6661-LY)

Datasheet SDS
Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A5
Application*: WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBLG1-2460) (CBMAB-G6662-LY)

Datasheet SDS
Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-2460
Application*: E, IF, P, WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBLG1-2461) (CBMAB-G6663-LY)

Datasheet SDS
Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-2461
Application*: E, WB

Mouse Anti-TSC22D3 Monoclonal Antibody (1G10) (CBMAB-0275-LY)

Datasheet SDS
Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 1G10
Application*: IP, E

Mouse Anti-TSC22D3 Recombinant Antibody (CBYCD-524) (CBMAB-D2352-YC)

Datasheet SDS
Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCD-524
Application*: WB, IC, P, C, E

Rat Anti-TSC22D3 Recombinant Antibody (CFMKG15) (CBMAB-H3891-FY)

Datasheet SDS
Target: TSC22D3
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CFMKG15
Application*: WB, F

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4977) (CBMAB-T4534-YJ)

Datasheet SDS
Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4977
Application*: WB, IH, IF

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4978) (CBMAB-T4535-YJ)

Datasheet SDS
Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4978
Application*: WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4979) (CBMAB-T4536-YJ)

Datasheet SDS
Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4979
Application*: WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4980) (CBMAB-T4537-YJ)

Datasheet SDS
Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4980
Application*: WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4981) (CBMAB-T4538-YJ)

Datasheet SDS
Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4981
Application*: E, IF, IH, IP, WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4982) (CBMAB-T4539-YJ)

Datasheet SDS
Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4982
Application*: IF, WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4983) (CBMAB-T4540-YJ)

Datasheet SDS
Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4983
Application*: WB

Mouse Anti-TSC22D3 Recombinant Antibody (2B2) (CBMAB-A9561-LY)

Datasheet SDS
Target: TSC22D3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B2
Application*: WB, E

TSC22D3 Matched Antibody Pair (1281) (APMAB-1281LY)

Datasheet SDS
Target: TSC22D3
Specificity: Human

TSC22D3 Matched Antibody Pair (1282) (APMAB-1282LY)

Datasheet SDS
Target: TSC22D3
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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