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Mouse Anti-TSFM Recombinant Antibody (V2-619042) (CBMAB-A9568-LY)

The product is antibody recognizes TSFM. The antibody 1A2 immunoassay techniques such as: WB, ELISA.
See all TSFM antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-619042
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
TSFM (NP_005717.2, 161 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ts translation elongation factor, mitochondrial
Introduction
Synthesis of the 13 mitochondrial-encoded proteins occurs on a dedicated mitochondrial translation apparatus similar to that found in prokaryotes and requires, in addition to the tRNAs and rRNAs encoded in mtDNA, the concerted action of several translation factors and a large number of mitochondrial ribosomal proteins, all of which are encoded by nuclear genes. The TSFM gene encodes a mitochondrial translation elongation factor (Smeitink et al., 2006 [PubMed 17033963]).[supplied by OMIM
Entrez Gene ID
10102
UniProt ID
P43897
Alternative Names
COXPD3; EF-TS; EF-Tsmt
Function
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Biological Process
Biological Process mitochondrial translational elongation Source:GO_Central1 Publication
Biological Process regulation of DNA-templated transcription elongation Source:ProtInc1 Publication
Biological Process regulation of mitochondrial translation Source:UniProtKB1 Publication
Biological Process translational elongation Source:GO_Central1 Publication
Cellular Location
Mitochondrion
Involvement in disease
Combined oxidative phosphorylation deficiency 3 (COXPD3):
A mitochondrial disease resulting in severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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