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Mouse Anti-TSFM Recombinant Antibody (CBYJT-4998) (CBMAB-T4555-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TSFM (Ts Translation Elongation Factor, Mitochondrial). The antibody can be used for immunoassay techniques, such as S-ELISA, ELISA.
See all TSFM antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4998
Antibody Isotype
IgG1, κ
Application
S-ELISA, ELISA

Basic Information

Immunogen
TSFM (NP_005717.2, 161 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 161-260

Target

Full Name
Ts translation elongation factor, mitochondrial
Introduction
TSFM is a mitochondrial translation elongation factor. TSFM is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in TSFM are associated with combined oxidative phosphorylation deficiency-3 syndrome.
Entrez Gene ID
10102
UniProt ID
P43897
Alternative Names
Ts Translation Elongation Factor, Mitochondrial; EF-TsMt; EF-Ts; Elongation Factor Ts, Mitochondrial; Mitochondrial Elongation Factor Ts; EFTSMT; EFTS
Function
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Biological Process
Biological Process mitochondrial translational elongation Source:GO_Central1 Publication
Biological Process regulation of DNA-templated transcription elongation Source:ProtInc1 Publication
Biological Process regulation of mitochondrial translation Source:UniProtKB1 Publication
Biological Process translational elongation Source:GO_Central1 Publication
Cellular Location
Mitochondrion
Involvement in disease
Combined oxidative phosphorylation deficiency 3 (COXPD3):
A mitochondrial disease resulting in severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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