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Rat Anti-Tsku Recombinant Antibody (CBYJT-5040) (CBMAB-T4615-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Tsku (Tsukushi, Small Leucine Rich Proteoglycan). The antibody can be used for immunoassay techniques, such as WB.
See all Tsku antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJT-5040
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse TSK
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Tsukushi, Small Leucine Rich Proteoglycan
Introduction
Tsku functions in processes like adenylate cyclase-modulating G-protein coupled receptor signaling pathway, anterior commissure morphogenesis, camera-type eye development, ciliary body morphogenesis, corpus callosum morphogenesis.
Entrez Gene ID
244152
UniProt ID
Q8CBR6
Alternative Names
Tsk; E2ig4; Lrrc54; 9530051K01Rik
Function
Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis.
Biological Process
Biological Process anterior commissure morphogenesis Source:UniProtKB
Biological Process bone growth Source:UniProtKB
Biological Process camera-type eye development Source:UniProtKB
Biological Process cholesterol efflux Source:UniProtKB
Biological Process cholesterol homeostasis Source:UniProtKB
Biological Process cholesterol metabolic process Source:UniProtKB
Biological Process ciliary body morphogenesis Source:UniProtKB
Biological Process corpus callosum morphogenesis Source:Ensembl
Biological Process energy homeostasis Source:UniProtKB
Biological Process growth plate cartilage chondrocyte development Source:UniProtKB
Biological Process hippocampus development Source:UniProtKB
Biological Process inner ear receptor cell stereocilium organization Source:UniProtKB
Biological Process lateral ventricle development Source:Ensembl
Biological Process negative regulation of myofibroblast differentiation Source:UniProtKB
Biological Process negative regulation of neuron projection development Source:UniProtKB
Biological Process negative regulation of transforming growth factor beta1 production Source:UniProtKB
Biological Process negative regulation of Wnt signaling pathway Source:UniProtKB
Biological Process positive regulation of hair cycle Source:UniProtKB
Biological Process regulation of gene expression Source:UniProtKB
Biological Process wound healing Source:UniProtKB
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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