TSKU

Tsku functions in processes like adenylate cyclase-modulating G-protein coupled receptor signaling pathway, anterior commissure morphogenesis, camera-type eye development, ciliary body morphogenesis, corpus callosum morphogenesis.

Full Name

Tsukushi, Small Leucine Rich Proteoglycan

Function

Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis.

Biological Process

Biological Process anterior commissure morphogenesis Source:UniProtKB
Biological Process bone growth Source:UniProtKB
Biological Process camera-type eye development Source:UniProtKB
Biological Process cholesterol efflux Source:UniProtKB
Biological Process cholesterol homeostasis Source:UniProtKB
Biological Process cholesterol metabolic process Source:UniProtKB
Biological Process ciliary body morphogenesis Source:UniProtKB
Biological Process corpus callosum morphogenesis Source:Ensembl
Biological Process energy homeostasis Source:UniProtKB
Biological Process growth plate cartilage chondrocyte development Source:UniProtKB
Biological Process hippocampus development Source:UniProtKB
Biological Process inner ear receptor cell stereocilium organization Source:UniProtKB
Biological Process lateral ventricle development Source:Ensembl
Biological Process negative regulation of myofibroblast differentiation Source:UniProtKB
Biological Process negative regulation of neuron projection development Source:UniProtKB
Biological Process negative regulation of transforming growth factor beta1 production Source:UniProtKB
Biological Process negative regulation of Wnt signaling pathway Source:UniProtKB
Biological Process positive regulation of hair cycle Source:UniProtKB
Biological Process regulation of gene expression Source:UniProtKB
Biological Process wound healing Source:UniProtKB

Cellular Location

Secreted