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Mouse Anti-TUBAL3 Recombinant Antibody (CBYJT-5253) (CBMAB-T4838-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5253
Antibody Isotype
IgG2b
Application
WB, IHC, IF, FC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 150-446 of human TUBAL3(NP_079079) produced in E. coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 150-446

Target

Full Name
Tubulin Alpha Like 3
Introduction
TUBAL3 (Tubulin Alpha Like 3) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling and EphB-EphrinB Signaling. Gene Ontology (GO) annotations related to TUBAL3 include GTP binding and structural constituent of cytoskeleton. An important paralog of TUBAL3 is TUBA1B.
Entrez Gene ID
79861
UniProt ID
A6NHL2
Alternative Names
Tubulin Alpha Like 3; Tubulin, Alpha-Like 3
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Biological Process
Biological Process microtubule cytoskeleton organization Source:GO_Central1 Publication
Biological Process mitotic cell cycle Source:GO_Central1 Publication
Cellular Location
Cytoplasm, cytoskeleton
PTM
Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group. Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Glutamylation is also involved in cilia motility (By similarity).
Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into cilia and flagella axonemes, which is required for their stability and maintenance. Flagella glycylation controls sperm motility. Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally.
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For research use only. Not intended for any clinical use.

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