TUBAL3

TUBAL3 (Tubulin Alpha Like 3) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling and EphB-EphrinB Signaling. Gene Ontology (GO) annotations related to TUBAL3 include GTP binding and structural constituent of cytoskeleton. An important paralog of TUBAL3 is TUBA1B.
Full Name
Tubulin Alpha Like 3
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Biological Process
Biological Process microtubule cytoskeleton organization Source:GO_Central1 Publication
Biological Process mitotic cell cycle Source:GO_Central1 Publication
Cellular Location
Cytoplasm, cytoskeleton
PTM
Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group. Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Glutamylation is also involved in cilia motility (By similarity).
Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into cilia and flagella axonemes, which is required for their stability and maintenance. Flagella glycylation controls sperm motility. Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally.
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Anti-TUBAL3 antibodies

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Mouse Anti-TUBAL3 Recombinant Antibody (CBYJT-5263) (CBMAB-T4848-YJ)

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Target: TUBAL3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5263
Application*: IF, WB
Datasheet SDS

Mouse Anti-TUBAL3 Recombinant Antibody (CBYJT-5262) (CBMAB-T4847-YJ)

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Target: TUBAL3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5262
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-TUBAL3 Recombinant Antibody (CBYJT-5261) (CBMAB-T4846-YJ)

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Target: TUBAL3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5261
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-TUBAL3 Recombinant Antibody (CBYJT-5260) (CBMAB-T4845-YJ)

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Target: TUBAL3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5260
Application*: F, P, WB
Datasheet SDS

Mouse Anti-TUBAL3 Recombinant Antibody (CBYJT-5259) (CBMAB-T4844-YJ)

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Target: TUBAL3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5259
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-TUBAL3 Recombinant Antibody (CBYJT-5258) (CBMAB-T4843-YJ)

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Target: TUBAL3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5258
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-TUBAL3 Recombinant Antibody (CBYJT-5257) (CBMAB-T4842-YJ)

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Target: TUBAL3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5257
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-TUBAL3 Recombinant Antibody (CBYJT-5256) (CBMAB-T4841-YJ)

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Target: TUBAL3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5256
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-TUBAL3 Recombinant Antibody (CBYJT-5255) (CBMAB-T4840-YJ)

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Target: TUBAL3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5255
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-TUBAL3 Recombinant Antibody (CBYJT-5254) (CBMAB-T4839-YJ)

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Target: TUBAL3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5254
Application*: WB, F
Datasheet SDS

Mouse Anti-TUBAL3 Recombinant Antibody (CBYJT-5253) (CBMAB-T4838-YJ)

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Target: TUBAL3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5253
Application*: WB, IH, IF, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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