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Mouse Anti-TUBGCP4 Recombinant Antibody (GT812) (CBMAB-G6678-LY)

This product is antibody recognizes TUBGCP4. The antibody GT812 immunoassay techniques such as: ICC, IF, WB.
See all TUBGCP4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
GT812
Antibody Isotype
IgG2b
Application
ICC, IF, WB

Basic Information

Immunogen
Recombinant protein fragment contains a sequence corresponding to a region within amino acids 1 and 178 of GCP4
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TUBGCP4 Gene(Protein Coding)


Tubulin Gamma Complex Associated Protein 4
Introduction
This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Entrez Gene ID
27229
UniProt ID
Q9UGJ1
Alternative Names
Tubulin Gamma Complex Associated Protein 4; Gamma-Ring Complex Protein 76 KDa; GCP-4; GCP4; 76P; Gamma Tubulin Ring Complex Protein (76p Gene); Tubulin; Gamma Complex Associated Protein 4;
Function
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
Biological Process
Biological Process cytoplasmic microtubule organization Source:GO_Central1 Publication
Biological Process meiotic cell cycle Source:GO_Central1 Publication
Biological Process microtubule nucleation Source:GO_Central1 Publication
Biological Process mitotic cell cycle Source:GO_Central1 Publication
Biological Process protein-containing complex assembly Source:ProtInc1 Publication
Biological Process spindle assembly Source:GO_Central1 Publication
Cellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Involvement in disease
Microcephaly and chorioretinopathy, autosomal recessive, 3 (MCCRP3):
A disorder characterized by congenital microcephaly and chorioretinal dysplasia associated with poor vision and nystagmus. Variable ocular anomalies include microphthalmia, retinal folding, retinal detachment, optic nerve hypoplasia, absence of retinal vessels, round areas of chorioretinal atrophy, and attenuated electroretinogram. Most patients have mild developmental delay and mild learning difficulties.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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