Mouse Anti-TWF1 Recombinant Antibody (CBYJT-5403) (CBMAB-T5006-YJ)

Name: Mouse Anti-TWF1 Recombinant Antibody (CBYJT-5403)
SKU: CBMAB-T5006-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-5403

Application

S-ELISA, ELISA, WB

Immunogen

PTK9 (AAH22344, 80 a.a. ~ 252 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 80-252

More Infomation

Target

Full Name

TWF1 Gene(Protein Coding) Twinfilin Actin Binding Protein 1

Introduction

TWF1 is twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that TWF1 may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.

Entrez Gene ID

5756

UniProt ID

Q12792

Alternative Names

Twinfilin Actin Binding Protein 1; Protein Tyrosine Kinase 9; PTK9 Protein Tyrosine Kinase 9; Protein A6; PTK9; Twinfilin, Actin-Binding Protein, Homolog 1 (Drosophila)

Function

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).

Biological Process

Biological Process actin filament depolymerization Source:GO_Central1 Publication
Biological Process barbed-end actin filament capping Source:GO_Central1 Publication
Biological Process negative regulation of actin filament polymerization Source:BHF-UCLBy Similarity
Biological Process positive regulation of cardiac muscle hypertrophy Source:Ensembl
Biological Process positive regulation of neuron projection development Source:GO_Central1 Publication
Biological Process regulation of actin phosphorylation Source:BHF-UCL1 Publication
Biological Process regulation of lamellipodium assembly Source:GO_Central1 Publication
Biological Process sequestering of actin monomers Source:BHF-UCLBy Similarity

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton
Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity).

Involvement in disease

Defects in TWF1 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.

PTM

Phosphorylated on serine and threonine residues.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TWF1 Matched Antibody Pair (1286) (CAT#: APMAB-1286LY)

TWF1 Matched Antibody Pair (1287) (CAT#: APMAB-1287LY)

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TWF1 Matched Antibody Pair (1286) (CAT#: APMAB-1286LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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