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TWF1

This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008]
Full Name
TWF1 Gene(Protein Coding) Twinfilin Actin Binding Protein 1
Function
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).
Biological Process
Biological Process actin filament depolymerization Source:GO_Central1 Publication
Biological Process barbed-end actin filament capping Source:GO_Central1 Publication
Biological Process negative regulation of actin filament polymerization Source:BHF-UCLBy Similarity
Biological Process positive regulation of cardiac muscle hypertrophy Source:Ensembl
Biological Process positive regulation of neuron projection development Source:GO_Central1 Publication
Biological Process regulation of actin phosphorylation Source:BHF-UCL1 Publication
Biological Process regulation of lamellipodium assembly Source:GO_Central1 Publication
Biological Process sequestering of actin monomers Source:BHF-UCLBy Similarity
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton
Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity).
Involvement in disease
Defects in TWF1 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.
PTM
Phosphorylated on serine and threonine residues.

Anti-TWF1 antibodies

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Mouse Anti-TWF1 Recombinant Antibody (CBYJT-5403) (CBMAB-T5006-YJ)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-5403
Application*: SE, E, WB

Mouse Anti-TWF1 Recombinant Antibody (7C11) (CBMAB-T5005-YJ)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7C11
Application*: E, WB, P, IF, IC, F

Mouse Anti-TWF1 Recombinant Antibody (CBYJT-5402) (CBMAB-T5004-YJ)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5402
Application*: WB

Mouse Anti-TWF1 Recombinant Antibody (CBYJT-5401) (CBMAB-T5003-YJ)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5401
Application*: WB, IH

Mouse Anti-TWF1 Recombinant Antibody (CBYJT-5400) (CBMAB-T5002-YJ)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5400
Application*: WB

Mouse Anti-TWF1 Recombinant Antibody (CBYJT-5399) (CBMAB-T5001-YJ)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5399
Application*: WB

Mouse Anti-TWF1 Recombinant Antibody (CBYJT-5398) (CBMAB-T5000-YJ)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5398
Application*: WB

Mouse Anti-TWF1 Recombinant Antibody (CBYJT-5397) (CBMAB-T4999-YJ)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-5397
Application*: E, WB

Mouse Anti-TWF1 Recombinant Antibody (CBYJT-5396) (CBMAB-T4998-YJ)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-5396
Application*: E, IF, WB

Mouse Anti-TWF1 Recombinant Antibody (CBYJT-5395) (CBMAB-T4997-YJ)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5395
Application*: WB

Mouse Anti-TWF1 Recombinant Antibody (CBYJT-5394) (CBMAB-T4996-YJ)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5394
Application*: E, F, IC, IH, WB

Mouse Anti-TWF1 Recombinant Antibody (5C12) (CBMAB-P3756-YC)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5C12
Application*: WB, IH

Mouse Anti-TWF1 Recombinant Antibody (5C4) (CBMAB-A7209-LY)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5C4
Application*: WB, E

Mouse Anti-TWF1 Recombinant Antibody (2B1) (CBMAB-A7208-LY)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 2B1
Application*: WB, E

Mouse Anti-TWF1 Recombinant Antibody (1D12) (CBMAB-A7207-LY)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D12
Application*: WB, E

Mouse Anti-TWF1 Recombinant Antibody (5E2) (CBMAB-A7206-LY)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 5E2
Application*: WB, E

Mouse Anti-TWF1 Recombinant Antibody (1E2) (CBMAB-A7205-LY)

Datasheet SDS
Target: TWF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E2
Application*: WB, E

TWF1 Matched Antibody Pair (1287) (APMAB-1287LY)

Datasheet SDS
Target: TWF1
Specificity: Human

TWF1 Matched Antibody Pair (1286) (APMAB-1286LY)

Datasheet SDS
Target: TWF1
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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